|
|
Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۱۲، صفحات ۱۲۶۲-۱۲۶۸
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Potential therapeutic effect of pomegranate seed oil on ovarian ischemia/reperfusion injury in rats |
|
| چکیده انگلیسی مقاله |
Objective(s): The aim of this study is to determine the therapeutic effects of pomegranate seed oil, which is a powerful antioxidant and anti-inflammatory agent, on ovarian-ischemia and reperfusion injury in rats.Materials and Methods: Fifty-six female albino Wistar rats were divided into 7 equal groups. Group 1; Sham Operation, Group 2; Ischemia, Group 3; Ischemia + Reperfusion, Group 4; Ischemia + Pomegranate 0,32 ml / kg (IP), Group 5; Ischemia + Pomegranate 0.64 ml / kg, Group 6; Ischemia + Pomegranate 0,32 ml / kg + reperfusion, Group 7; Ischemia + Pomegranate 0,64 ml / kg + reperfusion. Three hours after ischemia and 3 hours after reperfusion, the study was terminated. Results: While NADPH oxidase activity, MDA and TNF-α levels were significantly increased, SOD activity and GSH levels were reduced in ischemia and I/R groups. Low dose pomegranate seed oil application reduced significantly oxidative stress and NADPH oxidase activity in both ischemic and ischemic/reperfusion groups. At the same time, low-dose pomegranate seed oil extract reduced TNF-α levels and significantly increased antioxidant activity.Conclusion: PSO demonstrated an important therapeutic effect in the treatment of ovarian ischemia and reperfusion injury. |
|
| کلیدواژه‌های انگلیسی مقاله |
|
|
| نویسندگان مقاله |
| Muhammed Yayla
Department of Pharmacology, Faculty of Medicine, Kafkas University, Kars, Turkey
| Damla Cetin
Department of Pharmacology, Faculty of Medicine, Kafkas University, Kars, Turkey
| Yasemen Adali
Department of Pathology, Highlited sentences should be cahanged as Canakkale Onsekiz Mart University Faculty of Medicine, 17100 Canakkale/Turkey
| Pinar Aksu Kilicle
Department of Biology, Canakkale Onsekiz Mart University Faculty of Medicine, 17100 Canakkale/Turkey
| Erdem Toktay
Department of Histology and Embryology, Ataturk University, Faculty of Medicine, 25240 Erzurum/Turkey
|
|
| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_11675.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-967902.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Original Article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|