Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۱۰، صفحات ۱۰۱۳-۱۰۱۹
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عنوان انگلیسی Adiponectin alleviate blood hypercoagulability via inhibiting endothelial cell apoptosis induced by oxidative stress in septic rats
چکیده انگلیسی مقاله Objective(s): The purpose of this study was to detect the protective effects of adiponectin on coagulation dysfunction and its mechanism in sepsis of rats.Materials and Methods: The experimental samples were composed of sham group,   model group that was underwent cecal ligation and puncture (CLP) and three adiponectin treatment groups that treated by adiponectin with different dose (72 μg/kg, 96 μg/kg and 120 μg/kg) after CLP. The prothrombin time (PT), activated partial thromboplastin time (APTT) was measured, respectively, the level of malondialdehyde (MDA), tissue factor (TF), activated coagulation factor VIIa and Xa, p-selectin were detected, the histology structure of vascular was observed, the expressions of Caspase 9, Caspase 3, Bax, Bcl-2 and vWF in vascular were measured.Results: The results demonstrated that adiponectin treatment lengthened PT and APTT, reduced the expression of MDA, TF, activated coagulation factor VIIa, Xa and p-selectin in plasma of septic rats. Additionally, adiponectin treatment alleviated endothelial cell apoptosis and oxidative stress, down-regulated the levels of Caspase 3, Caspase 9, Bax, Bcl-2 and vWF in vascular.Conclusion: These findings suggest that adiponectin treatment might be a promising therapeutic strategy for relieving septic endothelial cell injury and coagulation dysfunction via inhibiting endothelial cell apoptosis in septic rats.
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نویسندگان مقاله | Yun Hou
Department of Histology and Embryology, Binzhou Medical University, Yantai, P R China


| Xi-Feng Wang
Department of Critical Care Medicine, Yu Huang Ding Hospital, Qingdao University, Yantai, P R China


| Zhi-Qiang Lang
Department of Pathology, Yu Huang Ding Hospital, Qingdao University, Yan Tai, P R China


| Wei Zhao
Department of Histology and Embryology, Binzhou Medical University, Yantai, P R China


| Yinchuan Jin
Department of Histology and Embryology, Binzhou Medical University, Yantai, P R China


| Hong-Qin Zhang
Department of Histology and Embryology, Binzhou Medical University, Yantai, P R China


| Lian-Shuang Zhang
Department of Histology and Embryology, Binzhou Medical University, Yantai, P R China
نشانی اینترنتی http://ijbms.mums.ac.ir/article_11356.html
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