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Iranian Journal of Otorhinolaryngology، جلد ۲۷، شماره ۲، صفحات ۹۵-۱۰۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Results of Acellular Dermis Matrix Graft Used for Tympanoplasty in Guinea Pig Model |
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| چکیده انگلیسی مقاله |
Introduction: To describe the underlay tympanoplasty technique using an acellular dermal graft(AlloDerm) for tympanic membrane (TM) reconstruction in a guinea pig model and to demonstrate the feasibility of the technique using AlloDerm tissue harvested from the prepuce as a source of tissue for future grafting in human TM reconstruction. Materials and Methods: The prepuce was divided during circumcision and the acellular dermis was prepared using a number of standard processes. Two groups of guinea pigs were prepared. In the case group (20 guinea pigs and 40 ears) removal of TM was performed with tympanoplasty using AlloDerm, and in the control group (eight guinea pigs and 16 ears), removal of TM was performed without tympanoplasty. In each group, the TM was completely removed in one ear and partially removed on the other side, and the integrity of the TMs was re-evaluated after 8 weeks. Results: In the case group, the healing rates in the completely and partially removed TMs were 83.3% and 94.4%, respectively. The difference in healing rate (0% and 66.7%, respectively) was statistically significant (P< 0.05). Conclusion: The use of AlloDerm is safe and effective in the repair of TM perforations in a guinea pig model. Acceptable results of AlloDerm tympanoplasty in a guinea pig model may pave the way for the effective use of this material in human TM reconstructions. |
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| کلیدواژه‌های انگلیسی مقاله |
Partial perforation, Total perforation, Tympanoplasty |
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| نویسندگان مقاله |
فرهاد فراهانی | farhad farahani
otolaryngology research center, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
علیرضا کریمی یزدی | alireza karimi yazdi
otolaryngology research center, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
محمد قاسمی | mohammad ghasemi
sinus and surgical endoscopic research center, ghaem hospital, school of medicine, mashhad university of medical sciences, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
الناز شریعت پناهی | elnaz shariatpanahi
department of otolaryngology, school of medicine, hamadan university of medical sciences amp;amp; health services, hamadan, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
عبدالمحمد کجباف زاده | abdol mohammad kajbafzadeh
pediatric urology research center, children’s hospital medical center, tehran university of medical science, tehran, iran.
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)
سعید امان پور | saeid amanpour
cancer model research center, cancer institute of iran, tehran university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
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| نشانی اینترنتی |
http://ijorl.mums.ac.ir/article_3580.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/11/article-11-80967.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original |
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