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Iranian Journal of Otorhinolaryngology، جلد ۲۸، شماره ۳، صفحات ۱۹۷-۲۰۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Investigating the Prevalence of Human Papilloma Virus in Squamous Cell Carcinoma of the Larynx and Its Correlation with Disease Prognosis |
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| چکیده انگلیسی مقاله |
Introduction: The human papilloma virus (HPV) can play a role in the development of head and neck squamous cell carcinoma (SCC). Our aim was to assess the prevalence of HPV DNA in SCC of the larynx. The impact of HPV infection on patient survival was also evaluated. Materials and Methods: This case-control study was performed in 44 patients with SCC of the larynx (case group), while the control group comprised samples obtained from cadavers with no previous history of malignancy. A preliminary pathologic evaluation was performed on all samples in the control group (36 samples) to ensure the absence of dysplasia or malignancy. Polymerase chain reaction (PCR) was used to detect HPV DNA. After completing the treatment protocol, patients were followed to assess the impact of HPV infection on overall survival (OS). Results: PCR evaluation in the case group showed that HPV DNA was successfully isolated from 11 (25%) samples, while only two (5.6%) HPV DNA-positive were obtained from cadavers. According to these results, a significant difference was obtained in the prevalence of HPV DNA and laryngeal SCC between cases and controls (P=0.031). No statistically significant difference was observed in the OS of patients with or without HPV infection in the case group (P=0.235). Conclusion: Based on these results, we suggest that the prevalence of HPV infection is higher in laryngeal SCC subjects compared with healthy individuals. Although a longer OS was seen in HPV-positive patients, survival analysis did not show a significant difference in the comparison of HPV-positive and negative findings in SCC patients. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
سعید atigheh chi | saeid atigheh chi
otorhinolaryngology research center, department of otorhinolaryngology, shahid sadoughi university of medical sciences, yazd, iran.
مجتبی میبدیان | mojtaba meybodian
otorhinolaryngology research center, department of otorhinolaryngology, shahid sadoughi university of medical sciences, yazd, iran.
محمد حسین داد gar نیا | mohamad hosein dad gar nia
otorhinolaryngology research center, department of otorhinolaryngology, shahid sadoughi university of medical sciences, yazd, iran.
محمد حسین برادران فر | mohamad hosein baradaran far
otorhinolaryngology research center, department of otorhinolaryngology, shahid sadoughi university of medical sciences, yazd, iran.
نسیم بهنیا فرد | nasim behnia fard
otorhinolaryngology research center, department of otorhinolaryngology, shahid sadoughi university of medical sciences, yazd, iran.
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| نشانی اینترنتی |
http://ijorl.mums.ac.ir/article_6854.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/11/article-11-80884.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
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