|
Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۹، صفحات ۹۴۳-۹۴۹
|
|
|
عنوان فارسی |
|
|
چکیده فارسی مقاله |
|
|
کلیدواژههای فارسی مقاله |
|
|
عنوان انگلیسی |
The possibility of using shogaol for treatment of ulcerative colitis |
|
چکیده انگلیسی مقاله |
Objective(s): This study aimed to investigate the effect of Shogaol on dextran sodium sulfate (DSS)- induced ulcerative colitis (UC) in mice compared to an immune-suppressant chemotherapeutic medicine, known as 6-thioguanine (6-TG). Materials and Methods: Thirty-six adult BALB/c mice were divided into six groups: group 1 (positive control): no DSS exposure and no treatment; group 2 (negative control): DSS exposure without treatment; group 3 (vehicle control): DSS exposure and olive oil treatment; group 4: DSS exposure and 0.3 mg/kg 6-TG treatment; group 5: DSS exposure and 20 mg/kg Shogaol treatment; and group 6: DSS exposure and 40 mg/kg Shogaol treatment. At day 16, the mice were euthanized and UC was evaluated according to colon length, histologically index score and expression scores of the epidermal growth factor receptor (EGFR).Results: The disease activity index (DAI) and histological index scores of mice treated with 40 mg/kg body weight (BW) Shogaol were approximately lower than the corresponding scores of mice treated with 6-TG. In addition, the rate of healing in the former mice was approximately 3 folds higher than that of the latter ones as indicated by the lack of EGFR expression in colonic glands and macrophages. Conclusion: These findings showed that the therapeutic effect of 40 mg/kg BW Shogaol could be better than 6-TG in the treatment of UC, and it may draw the attention regarding the priority of using this cheap plant-derived substance for treatment of the inflammatory bowel diseases because treatment with 6-TG is usually associated with adverse side effects. |
|
کلیدواژههای انگلیسی مقاله |
|
|
نویسندگان مقاله |
| Snur Hassan Department of Anatomy and Pathology, College of Veterinary Medicine, Sulaimani University, Kurdistan, Iraq
| Ali Hassan Department of Anatomy and Pathology, College of Veterinary Medicine, Sulaimani University, Kurdistan, Iraq
|
|
نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_11264.html |
فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-754240.pdf |
کد مقاله (doi) |
|
زبان مقاله منتشر شده |
en |
موضوعات مقاله منتشر شده |
|
نوع مقاله منتشر شده |
Original Article |
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|