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Iranian Journal of Medical Sciences، جلد ۲۹، شماره ۲، صفحات ۸۱-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Survival and Chemotactic Behavior of H pylori at Different Media pH |
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| چکیده انگلیسی مقاله |
Background: H pylori is a human gastric pathogen. Chemotaxis is an essential factor in colonization of H pylori , but very little is known about its chemotactic responses at different pH conditions, especially in acidic environment of stomach as its natural habitant. Methods: We first determined survival of H pylori under various pH conditions in the presence and absence of urea. Chemotaxis was then assayed in three strains of H pylori by modified Adler’s procedure, in which potassium bicarbonate was used as an attractant for estimating the chemotactic activity which was compared with phosphate buffer as an inert reagent. Results: H pylori cannot withstand pH 1, but in the presence of urea, it survives in solutions with pH values of2 to 9and remains viable at pH of 3 to 9, irrespective of presence of urea. Maximum chemotactic activity occurred at pH values of 5.5 to 6.5, whereas no chemotaxis was found in solutions with pH 3. Chemotactic activities are increased at pH 3 to 5.5 and reduced at pH 6 to 9, beyond which no chemotaxis was observed. Conclusion: In view of the fact that chemotaxis is severely affected by media pH, it is concluded that the antrum of the stomach is most suitable for colonization of H pylori for which maximum colonization occurs at neutral pH. |
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| نویسندگان مقاله |
o تجربه کار | o tadjrobehkar
zabol university of medical sciences, zabol, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی زابل (Zabol university of medical sciences)
عبداللهی | h abdollahi
microbiology dept, medical school, kerman university of medical sciences, kerman, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
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| نشانی اینترنتی |
http://ijms.sums.ac.ir/index.php/IJMS/article/view/2335 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-75019.pdf |
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| زبان مقاله منتشر شده |
en |
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| نوع مقاله منتشر شده |
Original Article(s) |
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