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Iranian Journal of Medical Sciences، جلد ۲۹، شماره ۲، صفحات ۷۵-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Nephrotoxicity of Isosorbide Dinitrate and Cholestasis in Rat: The Possible Role of Nitric Oxide |
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| چکیده انگلیسی مقاله |
Background: Nitric oxide (NO), a major chemical form of endothelium-derived relaxing factor and an important regulator of vascular tone, is released by endothelial cells. The role of NO is not restricted to the vascular system, and it participates in the regulation of renal hemodynamics and renal excretory function. There are increasing evidences indicating that the elevated levels of NO play a primary pathogenic role in the glomerular injury and renal failure. Objectives: We sought to investigate the renoprotective or nephrotoxic effects of various doses of isosorbide dinitrate as an exogenous model, and induction of cholestasis as an endogenous model of NO overproduction on renal function and structure. Methods: Parameters such as plasma and urine p-nitrophenyl-N-acetyl-β-D-glucosaminidase (NAG)-activity, urea and creatinine levels were measured. Results: Urea, creatinine and NAG-activity in rats treated by different doses of isosorbide as well as in cholestasis induced rats, were higher than control group. This elevation was significantly pronounced at higher doses of isosorbide. Conclusion: NO overproduction would be nephrotoxic due to oxidizing products of NO, peroxynitrite anion (ONOO – ), formed by the reaction of NO and superoxide radical (O 2 – ). |
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| نویسندگان مقاله |
a m شریفی | a m sharifi
department of pharmacology, school of medicine, endocrinology and metabolism research center emrc , dr shariati hospital, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
n اکبرلو | n akbarloo
department of pharmacology, school of medicine, endocrinology and metabolism research center emrc , dr shariati hospital, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
f ساسانی | f sasani
department of pathology, veterinary school, tehran university, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)
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| نشانی اینترنتی |
http://ijms.sums.ac.ir/index.php/IJMS/article/view/2334 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/147/article-147-75018.pdf |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article(s) |
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