Journal of Kerman University of Medical Sciences، جلد ۲۵، شماره ۱، صفحات ۱-۸

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عنوان انگلیسی A Randomized Clinical Trial of Using Niosomal Zinc Sulfate Plus Cryotherapy in Comparison With Placebo Along With Cryotherapy in Treatment of Common Wart
چکیده انگلیسی مقاله Background: There are different treatment modalities for common warts and all of them have side effects. Niosomal drug delivery systems have increased efficacy by enhanced transport of therapeutic agents through stratum corneum with decreased side effects. In this study, we assessed the efficacy of combined 2% niosomal zinc sulfate cream plus cryotherapy compared with combination of placebo plus cryotherapy. Methods: Sixty patients with verruca vulgaris enrolled in this randomized clinical trial study. Patients were divided in 2 groups. Group A received 2% niosomal zinc sulfate cream and group B received placebo twice a day. Also, patients in both groups were treated with cryotherapy (liquid nitrogen) every other week. Treatment protocols continued for a maximum of 3 months or until total clearance of the lesions. Results: Mean number of the sessions for complete remission was 4.5±1.38 in group A and 5.36±0.88 in group B and the difference between the two groups was statistically significant. Complete remission was observed in 60% in group A compared with 43.3% in group B that was not statistically significant. Conclusion: Combination therapy with niosomal zinc plus cryotherapy can lead to faster and greater percentage clearance of the lesions without significant increase in adverse effects in comparison with cryotherapy plus placebo.
کلیدواژه‌های انگلیسی مقاله Niosomal zinc sulfate, Wart treatment, Clinical trial

نویسندگان مقاله Ali Sharifi |
Department of Ophthalmology, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Azadeh Kazemipoor |
General Practitioner, Kerman University of Medical Sciences, Kerman, Iran

Hamid Sharifi |
HIV/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

Saeedeh Farajzadeh |
Professor of dermatology, Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran

Abbas Pardakhti |
Professor, Department of Pharmaceutics, School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran

Saman Mohammadi |
Assistant Professor of Dermatology, Department of Dermatology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Fahameh Fadaei |
Resident of Dermatology, Department of Dermatology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Maryam Khalili |
Assistant Professor of Dermatology, Department of Dermatology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

Azadeh Mohebbi |
Assistant Professor of Dermatology, Department of Dermatology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran

mahin aflatonian |
Assistant Professor of Dermatology, Department of Dermatology, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran


نشانی اینترنتی http://jkmu.kmu.ac.ir/article_63168_d79eeb1611676f3156667bd8897fb6bc.pdf
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