Iranian Journal of Basic Medical Sciences، جلد ۲۱، شماره ۳، صفحات ۲۴۴-۲۵۲
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی Chronic intermittent hypobaric hypoxia attenuates monocrotaline-induced pulmonary arterial hypertension via modulating inflammation and suppressing NF-κB /p38 pathway
چکیده انگلیسی مقاله Objective(s): Inflammation is involved in various forms of pulmonary arterial hypertension (PAH). Although the pathophysiology of PAH remains uncertain, NF-κB and p38 mitogen-activated protein kinase (p38 MAPK) has been reportedto be associated with many inflammatory mediators of PAH. This study aimed to evaluate the effect of chronic intermittent hypobaric hypoxia (CIHH) on pulmonary inflammation and remodeling in monocrotaline (MCT) induced PAH in rats. Materials and Methods: An in vivo model of PAH induced by MCT was employed. Statistical analyses were assessed bydone using one-way analysis of variance (ANOVA) or Fisher's LSD test for multiple comparisons. Results: Four weeks of CIHH exposure following MCT injection resulted in significant reduction of mean pulmonary artery pressure (mPAP) level and improvement of right ventricular hypertrophy (RVH). Morphometric analyses showed decreased wall thickness of pulmonary arterioles in MCT+CIHH treated rats. These findings are consistent with the decrease in Ki-67 immunostaining. Following CIHH treatments, apoptotic analysis showed a consistent decrease in T lymphocytes together with lower levels of CD4+ T cell subset as measured in spleen and blood samples. Furthermore, CIHH treatment resulted in markedly reduced expression of TNF-α and IL-6 via the inhibition of NF-κB and p38 MAPK activity in rat lungs. Conclusion: Altogether, these results provide new evidence relating to the mode of action of CIHH in the prevention of PAH induced by MCT.
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نویسندگان مقاله lei امتیاز | lei gao
department of heart center, the first hospital of hebei medical university, shijiazhuang, 050031, china


جون liu | jun liu
department of heart center, the first hospital of hebei medical university, shijiazhuang, 050031, china


yongmei hao | yongmei hao
department of endocrinology, the second hospital of hebei medical university, shijiazhuang, 050000, china


zengren zhao | zengren zhao
department of heart center, the first hospital of hebei medical university, shijiazhuang, 050031, china


huilian tan | huilian tan
department of heart center, the first hospital of hebei medical university, shijiazhuang, 050031, china


jie زانگ | jie zhang
department of heart center, the first hospital of hebei medical university, shijiazhuang, 050031, china


ning meng | ning meng
department of heart center, the first hospital of hebei medical university, shijiazhuang, 050031, china


qinghou zheng | qinghou zheng
department of heart center, the first hospital of hebei medical university, shijiazhuang, 050031, china


zhen ونگ | zhen wang
department of heart center, the first hospital of hebei medical university, shijiazhuang, 050031, china


yi زانگ | yi zhang
department of physiology, foundation medicine school of hebei medical university, shijiazhuang, 050017, china
نشانی اینترنتی http://ijbms.mums.ac.ir/article_10192.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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