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Journal of Kerman University of Medical Sciences، جلد ۲۴، شماره ۵، صفحات ۴۱۴-۴۱۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Frequency of factor V Leiden (G1691A) and prothrombin (G20210A) polymorphisms in Population of Kerman Province, Iran |
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| چکیده انگلیسی مقاله |
Background & Aims:Thromboembolism is an acute cardiovascular disease that ranges from clinically unimportant to massive embolism. Both acquired and hereditary risk factors contribute to the disease.
We aimed to determine the prevalence of two hereditary predisposing factor of the disease, prothrombin G20210A and factor V Leiden (G1691A) polymorphisms, in Kerman population. Methods:factor V and factor II genes of 112 healthy individuals were examined to detect factor V Leiden (G1691A) and prothrombin G20210A variants. Genomic DNA of subjects was isolated from leukocytes of the whole blood using salt-saturation method. We used amplification refractory mutation system technique to find G1691A and G20210A variations. Results: We found two subjects with prothrombin G20210A mutation and three individuals with factor V Leiden variant, both in heterozygote state. The frequency of the polymorphisms were 1.79 and 2.68, respectively. No homozygote or compound heterozygote individual was detected for these two variants in this study. Conclusion: our findings about the polymorphisms frequency were different from what was detected in other provinces of Iran or in some region of neighboring countries. This discrepancy of the variant frequency can be explained by gene flow phenomenon. |
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| کلیدواژه‌های انگلیسی مقاله |
Frequency,Factor V Leiden,Prothrombin G20210A |
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| نویسندگان مقاله |
نصراله صالح گوهری | saleh gohari
genetic department, afzalipour school of medicine, kerman university of medical sciences, kerman, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
ندا سلمانی cheharfarsakhi | salmani cheharfarsakhi
genetic laboratory, afzalipour school of medicine, kerman university of medical sciences, kerman, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
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| نشانی اینترنتی |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
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