Journal of Kerman University of Medical Sciences، جلد ۲۴، شماره ۵، صفحات ۳۸۹-۳۹۶

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عنوان انگلیسی Therapeutic effects of Lucilia sericata larvae on cutaneous leishmaniasis wounds caused by Leishmania major using BALB/c mice as animal model
چکیده انگلیسی مقاله Background: Cutaneous Leishmaniasis (CL) is an endemic disease in Iran. The pentavalent antimonials as first-line drugs are losing efficacy because of side effects, disease relapse and drug resistance. Application of Lucilia sericata larvae (maggot therapy) to diabetic and refractory wounds approved to be satisfactory for accelerating healing process. In this study, therapeutic effects of L. sericata maggot was evaluated in vivo against leishmanial ulcer using BALB/c mice as animal model. Methods: Female BALB/c mice were inoculated with promastigotes at the base of tails and kept for 28 days until the emergence of early ulcers. The mice were then underwent 4 treatments as follows: Glucantime alone, Glucantime plus maggots, maggot alone and positive control. The control and treated mice were monitored for a period of 5 weeks during which the wound diameters were measured and recorded on a weekly basis. Data were analyzed using Kolmogorov-Smirnov test and ANOVA T- test. Results: Statistical analysis showed significant difference (P
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نویسندگان مقاله محدثه کبیری |
msc in medical entomology, faculty of medical sciences, tarbiat modares university
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

محمدسعید دایر | mohammad saaid
assistant professor of medical entomology, faculty of medical sciences, tarbiat modares university
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)

فاطمه غفاری فر |
professor of parasitology, faculty of medical sciences, tarbiat modares university
سازمان اصلی تایید شده: دانشگاه تربیت مدرس (Tarbiat modares university)


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