| چکیده انگلیسی مقاله |
Objective(s): This study aims to investigate the pathogenicity and possible mechanisms of S100A9 function in mice models of scleroderma. Materials and Methods: The content of S100A9 in the skin tissues of mice with scleroderma was determined. Different concentrations of bleomycin (BLM) and S100A9 were subcutaneously injected into the backs of mice simultaneously, and then pathological changes in the skin of these mice were monitored. Specifically, the levels of inflammatory cytokines and alpha smooth muscle actin (α-SMA), the activation of extracellular regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) pathways, and the expression of the receptor for advanced glycation end-product (RAGE) in the skin were determined. Results: The content of S100A9 in the skin tissues of mice with scleroderma was determined. Different concentrations of BLM and S100A9 were subcutaneously injected into the backs of mice simultaneously, and then pathological changes in the skin of these mice were monitored. Specifically, the levels of inflammatory cytokines and alpha smooth muscle actin (α-SMA), the activation of extracellular regulated kinase 1/2 (ERK1/2) mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B (NF-κB) pathways, and the expression of the receptor for advanced glycation end-product (RAGE) in the skin were determined. Conclusion: S100A9 aggravates dermal fibrosis in BLM-induced scleroderma (BIS ) mice, and its mechanisms might be mediated by RAGE, ERK1/2, and NF-κB pathway. |
| نویسندگان مقاله |
xue xu | xue xu
department of rheumatology and immunology, nanjing drum tower hospital, the affiliated hospital of nanjing university medical school, nanjing 210008, jiangsu, china
zhiyong chen | zhiyong chen
department of rheumatology and immunology, nanjing drum tower hospital, the affiliated hospital of nanjing university medical school, nanjing 210008, jiangsu, china
xiaoxia zhu | xiaoxia zhu
division of rheumatology, huashan hospital, fudan university, shanghai 200040, china
dandan ونگ | dandan wang
department of rheumatology and immunology, nanjing drum tower hospital, the affiliated hospital of nanjing university medical school, nanjing 210008, jiangsu, china
جون liang | jun liang
department of rheumatology and immunology, nanjing drum tower hospital, the affiliated hospital of nanjing university medical school, nanjing 210008, jiangsu, china
چنگ zhao | cheng zhao
department of rheumatology and immunology, nanjing drum tower hospital, the affiliated hospital of nanjing university medical school, nanjing 210008, jiangsu, china
xuebing feng | xuebing feng
department of rheumatology and immunology, nanjing drum tower hospital, the affiliated hospital of nanjing university medical school, nanjing 210008, jiangsu, china
jiucun ونگ | jiucun wang
state key laboratory of genetic engineering and ministry of education key laboratory of contemporary anthropology, school of life sciences, fudan university, shanghai 200433, china
hejian zou | hejian zou
division of rheumatology, huashan hospital, fudan university, shanghai 200040, china
lingyun سون | lingyun sun
department of rheumatology and immunology, nanjing drum tower hospital, the affiliated hospital of nanjing university medical school, nanjing 210008, jiangsu, china
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