|
|
Iranian Journal of Nursing and Midwifery Research، جلد ۲۱، شماره ۱، صفحات ۱۰۰-۰
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
The effect of vitamin D supplementation on blood sugar and different indices of insulin resistance in patients with non‑alcoholic fatty liver disease (NAFLD) |
|
| چکیده انگلیسی مقاله |
Abstract Background: Vitamin D supplementation has been shown to decrease insulin resistance through which it might cause fatty liver. Fatty liver increasingly results in type 2 diabetes mellitus (T2DM). Insulin resistance and fatty liver are particularly closely related. The aim of present study is to examine the effect of vitamin D supplementation on blood sugar and different indices of insulin resistance in patients with non‑alcoholic fatty liver disease (NAFLD). Materials and Methods: This randomized placebo‑controlled clinical trial was conducted on 60 patients with NAFLD, who were divided equally into intervention and control groups. Patients in the intervention group received vitamin D3 (50,000 IU) and patients in the control group received placebo capsules every week for 10 weeks. Blood sugar, homeostatic model assessment‑insulin resistance (HOMA‑IR), and homeostatic model assessment‑beta cell (HOMA‑B) were checked at baseline and after 10 weeks of the intervention. Adjustment for variables was performed by analysis of covariance (ANCOVA). Results: Vitamin D supplementation resulted in increased serum 25‑hydroxy vitamin D [25(OH) D] concentration in the intervention group compared to the control group [+68 (12) vs. −1.9 (2.44); P = 0.001]. Intake of vitamin D supplements led to a marginally significant decrease in fasting blood glucose [FBS: −12 (4) in the intervention group compared to − 3 (2) in the control group; P = 0.055]. Also, HOMA‑IR decreased in the intervention group compared to the control group [−1.75 (0.23) vs. 0.12 (0.41); P = 0.066]. Conclusions: Vitamin D supplementation resulted in decreased HOMA‑IR and FBS concentration in patients with NAFLD; however, it did not affect the insulin level and HOMA‑B significantly. |
|
| کلیدواژه‌های انگلیسی مقاله |
|
|
| نویسندگان مقاله |
مهدی فروغی | mehdi foroughi
زهرا مقصودی | zahra maghsoudi
غلامرضا عسکری | gholamreza askari
|
|
| نشانی اینترنتی |
http://www.ijnmr.mui.ac.ir/index.php/ijnmr/article/view/1285 |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/113/article-113-55722.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Original Article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|