| چکیده انگلیسی مقاله |
Objective(s): To evaluated the effects of melatonin on early embryo competence and the expression rate of the primary implantation receptors (ErbB1 and ErbB4). Materials and Methods: Two-cell mouse embryos were cultured in 3 groups: simple media, melatonin-treated (10-9 M melatonin) and Luzindole-treated (10-9 M luzindole). Then, the rate of ErbB1 and ErbB4 gene and protein expression, the level of intracellular ROS, antioxidant capacity, and also the number of cells were evaluated and compared with the fourth group in vivo developed blastocysts (control group). Results: We concluded that melatonin significantly up-regulated the ErbB1 and ErbB4 gene and protein expression, decreased intracellular ROS, increased the total antioxidant capacity, and also elevated the cell numbers in the melatonin-treated group compared with the other groups (P≤0.05). Conclusion: The use of melatonin may be a helpful factor in improving the embryo quality and enhancing the expression of ErbB1 and ErbB4, two important implantation-related genes and proteins. |
| نویسندگان مقاله |
غزاله مشکدانیان | ghazaleh moshkdanian
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran|anatomical science research center, kashan university of medical sciences, kashan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)
فاطمه مغنی قرقی | fatemeh moghani ghoroghi
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
پریچهر پاسبخش | parichehr pasbakhsh
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سید نورالدین نعمت اللهی ماهانی | seyed noureddin nematollahi mahani
department of anatomy, afzalipour school of medicine, kerman university of medical sciences, kerman, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
عاطفه نجفی | atefeh najafi
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iranv
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
ایرج راگردی کاشانی | iraj ragerdi kashani
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
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