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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۱۰، صفحات ۱۰۷۴-۱۰۷۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Is precocious puberty linked to hypothalamic expression of arginine-phenylalanine-amide-related peptide? |
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| چکیده انگلیسی مقاله |
The up-regulator regulation and down-regulator regulation of gonadotropin-releasing hormone (GnRH) in central precocious puberty is not yet known. However, recent advances in neuroendocrinology have shown the controlling role of arginine-phenylalanine (RF)-amide-related peptides (RFRPs) on GnRH secretion in different phenomenon of reproduction such as estrus cycle and pregnancy, but the exact role of RFRPs in puberty and its related pathologic condition, precocious puberty, is not clear yet. This paper hypothesizes that RFRP is a regulatory peptide of puberty and might prevent the precocious puberty. On the basis of previous studies on hormonal fluctuations at the time of puberty, RFRP might have a role on controlling of premature secretion of GnRH and avoiding central precocious puberty. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
yuanyuan he | yuanyuan he
department of traditional chinese medicine, children’s hospital of fudan university, shanghai, 200032, china
wen سون | wen sun
department of traditional chinese medicine, children’s hospital of fudan university, shanghai, 200032, china
ژیان yu | jian yu
department of traditional chinese medicine, children’s hospital of fudan university, shanghai, 200032, china
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_9397.html |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Mini Review |
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