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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۱۱، صفحات ۱۲۲۷-۱۲۳۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Protective effects of piperine on lead acetate induced-nephrotoxicity in rats |
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| چکیده انگلیسی مقاله |
Objective(s): In this study, we investigated the protective effects of piperine on lead acetate-induced renal damage in rat kidney tissue. Materials and Methods: Forty male rats were divided into 5 groups: negative control (rats were given aquadest daily), positive control (rats were given lead acetate 30 mg/kg BW orally once a day for 60 days), and the treatment group (rats were given piperine 50 mg; 100 mg and 200 mg/kg BW orally once a day for 65 days, and on 5th day, were given lead acetate 30 mg/kg BW one hr after piperine administration for 60 days). On day 65 levels of blood urea nitrogen (BUN), creatinine, malondialdehyde (MDA), Superoxide Dismutase (SOD), and Glutathione Peroxidase (GPx) were measured. Also, kidney samples were collected for histopathological studies. Results: The results revealed that lead acetate toxicity induced a significant increase in the levels of BUN, creatinine, and MDA; moreover, a significant decrease in SOD and GPx. Lead acetate also altered kidney histopathology (kidney damage, necrosis of tubules) compared to the negative control. However, administration of piperine significantly improved the kidney histopathology, decreased the levels of BUN, creatinine, and MDA, and also significantly increased the SOD and GPx in the kidney of lead acetate-treated rats. Conclusion: From the results of this study it was concluded that piperine could be a potent natural herbal product exhibiting nephroprotective effect against lead acetate induced nephrotoxicity in rats. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
sri agus sudjarwo | sri agus sudjarwo
department of pharmacology, faculty of veterinary medicine, airlangga university, surabaya 60115 indonesia
koerniasari eraiko | koerniasari eraiko
department of conservative dentistry, faculty of dentistry, airlangga university, surabaya 60115 indonesia
giftania wardani sudjarwo | giftania wardani sudjarwo
department of pharmacy biology, faculty of pharmacy, hang tuah university, surabaya 60115 indonesia
koerniasari | koerniasari
study program of environmental health, polytechnic of health, surabaya 60115 indonesia
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_9487.html |
| فایل مقاله |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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