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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۱۱، صفحات ۱۱۸۲-۱۱۸۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Quetiapine reverse paclitaxel-induced neuropathic pain in mice: Role of Alpha2- adrenergic receptors |
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| چکیده انگلیسی مقاله |
Objective(s): Paclitaxel-induced peripheral neuropathy is a common adverse effect of cancer chemo -therapy. This neuropathy has a profound impact on quality of life and patient's survival. Preventing and treating paclitaxel-induced peripheral neuropathy is a major concern. First- and second-generation antipsychotics have shown analgesic effects both in humans and animals. Quetiapine is a novel atypical antipsychotic with low propensity to induce extrapyramidal or hyperprolactinemia side effects. The present study was designed to investigate the effects of quetiapine on the development and expression of neuropathic pain induced by paclitaxel in mice and the role of α2-adrenoceptors on its antinociception. Materials and Methods: Paclitaxel (2 mg/kg IP) was injected for five consecutive days which resulted in thermal hyperalgesia and mechanical and cold allodynia. Results: Early administration of quetiapine from the 1st day until the 5th day (5, 10, and 15 mg/kg PO) did not affect thermal, mechanical, and cold stimuli and could not prevent the development of neuropathic pain. In contrast, when quetiapine (10 and 15 mg/kg PO) administration was started on the 6th day after the first paclitaxel injections, once the model had been established, and given daily until the 10th day, heat hyperalgesia and mechanical and cold allodynia were significantly attenuated. Also, the effect of quetiapine on heat hyperalgesia was reversed by pretreatment with yohimbine, as an alpha-2 adrenergic receptor antagonist. Conclusion: These results indicate that quetiapine, when administered after nerve injury can reverse the expression of neuropathic pain. Also, we conclude that α2-adrenoceptors participate in the antinociceptive effects of quetiapine. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
علیرضا عابد | alireza abed
department of pharmacology, school of medicine, kashan university of medical sciences, kashan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)
محمد جواد خوشنود | mohammad javad khoshnoud
department of toxicology and pharmacology, school of pharmacy, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
مهدی تقیان | mehdi taghian
department of oral and maxillofacial surgery, school of dentistry, mazandaran university of medical science, sari, iran
سازمان اصلی تایید شده: دانشگاه مازندران (Mazandaran university)
محبوبه علی عسگرزاده | mahbubeh aliasgharzadeh
school of pharmacy, international branch, shiraz university of medical sciences, shiraz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)
اعظم مصداقی نیا | azam mesdaghinia
physiology research center, kashan university of medical sciences, kashan, iran|department of pharmacology, school of medicine, kashan university of medical sciences, kashan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کاشان (Kashan university of medical sciences)
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_9500.html |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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