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Iranian Journal of Otorhinolaryngology، جلد ۲۹، شماره ۴، صفحات ۱۸۹-۱۹۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Maternal Risk Factors Associated with the Development of Cleft Lip and Cleft Palate in Mexico: A Case-Control Study |
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| چکیده انگلیسی مقاله |
Introduction: Cleft lip and palate, the most common developmental deformity, is seen worldwide and the etiology involves a combination of genetic and environmental factors. The purpose of this study was to determine the maternal risk factors associated with the development of cleft lip and cleft palate. Materials and Methods: We conducted a case control study at the Women's Hospital in Culiacan, Mexico. Medical records were analyzed, including patients who delivered babies with and without cleft lip and cleft palate from January 2010 to December 2015. Multiple variables were analyzed, including gestational age, weight at birth, the use of folic acid and multivitamins during pregnancy, smoking, alcohol abuse, the use of recreational drugs, history of sexually transmitted infections, marital status, socioeconomic status, education, and nutritional status. Results: We found that the maternal risk factors with the strongest association for the development of cleft lip and cleft palate were the following: patients who were not taking folic acid during pregnancy [OR 3.27, 95% CI 1.32-8.09], P=0.00; patients who were not taking vitamin supplementation during pregnancy [OR 2.6, 95% CI 1.19-7.27], P=0.02; smoking during pregnancy [OR 2.05, 95% CI 1.23-3.41], P=0.01; and alcohol abuse during pregnancy [OR 1.90, 95% CI 1.17-3.08], P=0.03. Conclusions: The main risk factors associated with the development of cleft lip and cleft palate in a Mexican population at the Women's hospital in Culiacan, Sinaloa, Mexico were smoking, alcohol abuse, and patients not taking folic acid and multivitamins during pregnancy. |
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| کلیدواژه‌های انگلیسی مقاله |
Cleft lip, Cleft palate, Pregnancy complications |
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| نویسندگان مقاله |
emmanuel angulo castro | emmanuel angulo castro
department of perinatology, the women amp;apos;s hospital, secretariat of health, 80127, culiacan, sinaloa, mexico.
لوییس f acosta alfaro | luis f acosta alfaro
department of perinatology, the women amp;apos;s hospital, secretariat of health, 80127, culiacan, sinaloa, mexico.
آلما guadron llanos | alma guadron llanos
ciasap, school of medicine, autonomous university of sinaloa, 80246, culiacan, sinaloa, mexico
adrian canizalez roman | adrian canizalez roman
research department, the women amp;apos;s hospital, secretariat of health, 80127, culiacan, sinaloa, mexico
فرناندو گونزالس ibarra | fernando gonzalez ibarra
department of internal medicine, gulf coast medical center, panama city, 32405, florida, usa.
ignacio osuna ramirez | ignacio osuna ramirez
faculty of biological and chemical sciences, autonomous university of sinaloa, 80000 culiacán, sin, mexico.
ژول murillo llanes | joel murillo llanes
research department, the women amp;apos;s hospital, secretariat of health, 80127, culiacan, sinaloa, mexico
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| نشانی اینترنتی |
http://ijorl.mums.ac.ir/article_8925.html |
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| زبان مقاله منتشر شده |
en |
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| نوع مقاله منتشر شده |
Original |
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