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Iranian Journal of Otorhinolaryngology، جلد ۲۹، شماره ۶، صفحات ۳۲۷-۳۳۱
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چکیده فارسی مقاله |
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کلیدواژههای فارسی مقاله |
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عنوان انگلیسی |
Otologic Manifestations in Patients with Wegener Granulomatosis: A Survey in 55 Patients |
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چکیده انگلیسی مقاله |
Introduction: Granulomatosis with polyangiitis (GPA; also known as Wegener's granulomatosis) is a primary systemic vasculitis involving the ear, nose and throat system (ENT) and lower respiratory tract. Because of the lack of knowledge regarding the clinical findings of GPA due to the limited number of studies, the current study was designed to investigate the prevalence and nature of the otology manifestations in the disease course. Materials and Methods: In the current prospective study, patients with a diagnosis of GPA from 2012–2016 were included. A definitive diagnosis was made based on the history, physical examination (otomicroscopy, Rinne and Weber test), audiometry, tympanometry, cytoplasmic and perinuclear anti-neutrophil cytoplasmic antibody (C-ANCA and P-ANCA) investigations, and pathologic studies. Results: Twenty-seven male and 28 female patients aged 41.6±15.3 years were enrolled. Ear involvement was found in 20 patients (36.3%), and the most prevalent symptom was loss of hearing followed by otalgia and tinnitus. Tinnitus improved in none of the patients. The most prevalent sign was otitis serous followed by mastoiditis and external otitis. The most important audiometry finding was sensorineural hearing loss. Pathological studies using pulmonary samples were more useful for diagnosis. Conclusions: Precise clinical examination is crucial for the early diagnosis of GPA. Otological manifestations are common, especially loss of hearing and otitis serous, and can be the first sign of this disease. Early diagnosis can lead to better treatment of Wegener's granulomatosis. |
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کلیدواژههای انگلیسی مقاله |
Ear, Wegener’s granulomatosis, Vasculitis |
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نویسندگان مقاله |
علی صفوی نایینی | ali safavi naeeni chronic respiratory diseases research center, nritld, masih daneshvari hospital, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
جهانگیر قربانی | jahangir ghorbani chronic respiratory diseases research center, nritld, masih daneshvari hospital, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
سیما منتظر لطف الهی | sima montazer lotfe elahi chronic respiratory diseases research center, nritld, masih daneshvari hospital, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
محسن بیگمی | mohsen beigomi orthopedic surgeon, akhtar hospital, shahid beheshti university of medical sciences, tehran, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)
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نشانی اینترنتی |
http://ijorl.mums.ac.ir/article_9562.html |
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زبان مقاله منتشر شده |
en |
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نوع مقاله منتشر شده |
Original |
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