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Iranian Journal of Basic Medical Sciences، جلد ۱۰، شماره ۳، صفحات ۱۸۹-۱۹۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Evaluation of Antidepressant Effects of Aerial Parts of Echium vulgare on Mice |
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| چکیده انگلیسی مقاله |
Objective In traditional medicine, Echium spp., including E. vulgare L., are utilized as exhilarant and mood stimulant. On the other hand, depression is a state of intense sadness, melancholia or despair that has advanced to the point of being disruptive to an individual's social functioning and/or activities of daily living. Therefore, finding effective and safe treatments is a hotly contested area in the present time. In this study, the antidepressant effects of aqueous and alcoholic extracts of Echium vulgare L. aerial parts were investigated on mice. Materials and Methods Boiling and percolation were used for aqueous and alcoholic extractions, respectively. Toxicity and anti-depressant studies were performed in male BALB/C mice. Three doses of 0.05, 0.2 and 0.35 g/kg for aqueous extracts and five doses of 0.01, 0.04, 0.07, 0.3 and 0.5 g/kg for alcoholic extracts were selected in the forced swimming test employing 8 mice in each group. Open field activity test was used to differentiate antidepression and locomotion effects. ANOVA and Tukey-Kramer tests were used for statistical analysis. Results The LD50 values of aqueous and ethanolic extracts were 1.22 g/kg and 1.21 g/kg, respectively. Aqueous and alcoholic extracts showed significant antidepressant effects starting at 0.05 g/kg and 0.07 g/kg, respectively. Open field test showed no significant changes in the activities of animals which received the ethanolic extract, but the aqueous extract decreased locomotor activities at higher doses. Conclusion The results showed that the aqueous extract at low doses and ethanolic extract at high doses have significant antidepressant effects. The effects of extracts were similar to imipramine and they may affect neurotransmitters, norepinephrine and serotonin. This herb might be considered as a useful drug in the management of depression. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
سید عادل معلم | seyed adel moallem
department of pharmacodynamy amp;amp; toxicology, school of pharmacy, medical toxicology research center, pharmaceutical research center, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
حسین حسین زاده | hossein hosseinzadeh
department of pharmacodynamy amp;amp; toxicology, school of pharmacy, pharmaceutical research center, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
فاطمه غنچه | fatemeh ghoncheh
pharmacist
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_5294.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45906.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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