| چکیده انگلیسی مقاله |
Objective Vitamin E is a major lipid-soluble antioxidant. It has been demonstrated that vitamin E supplementation has a beneficial effect against coronary heart disease (CHD). This study to investigate the effects of coronary risk factors on serum vitamin E status in patients with dyslipidaemia. Materials and Methods This tertiary care hospital; case - control study was comprised 237 dyslipidaemic patients and 135 healthy individuals recruited from university and hospital employees. Serum vitamin E concentration was measured using high performance liquid chromatography (HPLC). Results Compared to the healthy individuals, the dyslipidaemic patients had higher serum vitamin E (p< 0.001), but serum vitamin E / total cholesterol ratio did not differ between patients and healthy controls (p>0.05). Serum vitamin E did not differ between subcategories of dyslipidaemic patients with and without coronary risk factors (p>0.05), but Serum vitamin E / total cholesterol ratio was higher in patients with established coronary heart disease (p< 0.01), hypertriglyceridaemia (p< 0.05) and metabolic syndrome (p< 0.05). In the patients there was not a strong association between serum vitamin E or serum vitamin E / total cholesterol ratio and coronary risk factors except for the serum cholesterol. Conclusion Serum vitamin E or vitamin E / total cholesterol ratio is not associated with the risk of coronary heart disease. Therefore, higher serum vitamin E or vitamin E / total cholesterol ratio doesn’t seem to have a preventive role against coronary heart disease. |
| نویسندگان مقاله |
مجید غیور مبرهن | majid ghayour mobarhan
cardiovascular research center, avicenna research institute, mashhad university of medical sciences mums , mashhad, iran|department of nutrition and biochemistry, faculty of medicine, mums, mashhad, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
امیرحسین صاحبکار | amir hossein sahebkar
school of pharmacy, mums, mashad, iran, postal code 91775-1365
بریان starkey | bryan starkey
centre for clinical science amp;amp; measurement, university of surrey, stag hill, guildford, surrey, gu2 7xh, united kingdom
callum livingstone | callum livingstone
centre for clinical science amp;amp; measurement, university of surrey, stag hill, guildford, surrey, gu2 7xh, united kingdom
تیم ونگ | tim wang
centre for clinical science amp;amp; measurement, university of surrey, stag hill, guildford, surrey, gu2 7xh, united kingdom
دیوید lamb | david lamb
centre for clinical science amp;amp; measurement, university of surrey, stag hill, guildford, surrey, gu2 7xh, united kingdom
گوردون ferns | gordon ferns
centre for clinical science amp;amp; measurement, university of surrey, stag hill, guildford, surrey, gu2 7xh, united kingdom
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