|
|
Iranian Journal of Basic Medical Sciences، جلد ۱۳، شماره ۴، صفحات ۲۰۰-۲۰۶
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Effects of Administration of Perinatal Bupropion on the Population Spike Amplitude in Neonatal Rat Hippocampal Slices |
|
| چکیده انگلیسی مقاله |
Objective(s) Bupropion is an atypical antidepressant that is widely used in smoke cessation under FDA approval. The study of synaptic effects of bupropion can help to finding out its mechanism(s) for stopping nicotine dependence. In this study the effects of perinatal bupropion on the population spike (PS) amplitude of neonates were investigated. Materials and Methods Hippocampal slices were prepared from 18-25 days old rat pups. The experimental groups included control and bupropion-treated. Bupropion (40 mg/Kg, i.p.) was applied daily in perinatal period as pre-treatment. Due to the studying acute effects, bupropion was also added to the perfusion medium (10, 50, 200 pM for 30 min). The evoked PS was recorded from pyramidal layer of CA1 area, following stimulation of Schaffer collaterals. Results A concentration of 10 pM bupropion had no significant effects on the PS amplitude. The 50 pM concentration of bupropion reduced the amplitude of responses in 50% of the studied cases. At a concentration of 200 pM, the recorded PS amplitudes were reduced in all slices (n= 22). Amplitude was completely abolished in 8 out of the 22 slices. The decrease of the PS amplitude was found to be more in the non-pre-treated slices than in the pre-treated slices when both were perfused with 200 pM bupropion. Conclusion The results showed the perinatal exposure to bupropion and its acute effects while indicating that at concentrations of 50 and 200 pM bupropion reduced the PS amplitude. It was also found that there was evidence of synaptic adaptation in comparison of bupropion-treated and non-treated slices whereas they were both perfused with 200 pM. |
|
| کلیدواژه‌های انگلیسی مقاله |
Bupropion, Hippocampus, Population Spike, Rat, Slice |
|
| نویسندگان مقاله |
سمیه heysieat طلب | soomaayeh heysieat talab
department of biology, faculty of science, urmia university, urmia, iran
سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)
صمد زارع | samad zare
department of biology, faculty of science, urmia university, urmia, iran
سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)
فیروز قادری پاکدل | firouz ghaderi pakdel
department of physiology, faculty of medicine, urmia university of medical sciences, urmia, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ارومیه (Urmia university of medical sciences)
مینا مختاری هشتجین | mina mokhtari hashtjin
department of biology, faculty of science, urmia university, urmia, iran
سازمان اصلی تایید شده: دانشگاه ارومیه (Urmia university)
|
|
| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_5114.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45799.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Original Article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|