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Iranian Journal of Basic Medical Sciences، جلد ۱۴، شماره ۱، صفحات ۸۹-۹۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
The Effect of MS14 on Production of Pro-inflammatory Cytokines by Macrophages |
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| چکیده انگلیسی مقاله |
Objective(s) Using herbal medicines as a complementary treatment method is increasing in wide variety of diseases. MS14-an herbal-marine preparation-is reported to have anti-inflammatory and immunomodulatory activities; however, the mechanism underlying its therapeutic effect is not known. Macrophages play an important role in host defense mechanisms and carry out their role by producing various mediators including proinflammatory cytokines (TNFα, IL-1β). In this study the effects of orally administered MS14 on TNFα and IL-1β production of BALB/c mice peritoneal macrophages were evaluated. Materials and Methods MS14 at 100 mg/kg was orally administered for 5 days to BALB/c mice in MS14 group. Sterile normal saline was administered to mice in control group. Peritoneal macrophage were isolated from control and MS14 groups and cultured, then the supernatants were collected and the cytokines IL-1β and TNFα were measured by ELISA test. Results Significant decrease in TNFα and IL-1β production of macrophages both at the presence and absence of stimulators was observed. TNFα levels were 64.7±4.6 and 51.1±4.2 pg/ml in drug and control groups respectively (P< 0.05) and 298.7±31.3 and 177.0±26.5 pg/ml in stimulated (PMA+fMLP) cultures of drug and control groups respectively (P< 0.007). The IL-1β levels was 130.1±2.8 pg/ml in control and 65.1±5.6 in MS14 group (P< 0.000). Conclusion It could be concluded that MS14 is able to cause a decline in some inflammatory responses of immune system, which could be considered as at least one of its immunomodulatory mechanisms. |
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| نویسندگان مقاله |
رویا یارایی | roya yaraee
department of immunology, medical school and medicinal plant research center, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)
نیره عسکری | nayere askari
department of biology, faculty of basic sciences, shahid bahonar university, kerman, iran
سازمان اصلی تایید شده: دانشگاه شهید باهنر (Shahid bahonar university)
محسن ناصری | mohsen naseri
department of pharmacology and department of iranian traditional medicine, medical school, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_4969.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45791.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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