|
|
Iranian Journal of Basic Medical Sciences، جلد ۱۴، شماره ۱، صفحات ۳۵-۴۱
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Lectin Histochemical Study of Vasculogenesis During Rat Pituitary Morphogenesis |
|
| چکیده انگلیسی مقاله |
Objective(s) The aim of this study was to investigate glycoconjugates distribution patterns as well as their changes during the course of pituitary portal vasculogenesis and angiogenesis. Materials and Methods Formalin fixed paraffin sections of 10 to 20 days of Sprague Dawly rat fetuses were processed for histochemical studies using four different horseradish peroxidase (HRP) conjugated lectins. Orange peel fungus (OFA), Vicica villosa (VVA), Glycine max (SBA) and Wistaria floribunda (WFA) specific for α-L Fucose, D-Gal, α, ß-D-GalNAc and D- GalNAc terminal sugars of glycoconjugates respectively. Results Our finding indicated that adenohypophysal cells reacted with OFA on gestational day 10 (E10) and increased progressively to E14. Staining intensity did not change from days 14 to17, then after increased following days to E20 significantly (P< 0.05). A few cells around Rathke’s pouch reacted with VVA on E13, increased to E14 and decreased significantly afterward (P< 0.05). Reaction of some cells around Rathke’s pouch reacted with SBA on E14. This visible reaction was the same as E18 and decreased later (P< 0.05). Many cells around Rathke’s pouch reacted with WFA on E13 and increased on E 14 and E15 and decreased thereafter (P< 0.05). Conclusion Reactions of OFA and other tested lectins with endothelial cells around Rathke’s pouch and developing pars distalis were different. These results suggest that embryonic origin of hypophiseal pituitary portal (HPP) system endothelial cells are not the same and our finding also indicated that glycoconjugates with terminal sugars α-L-Fucose, D-Gal, α, ß-D-GalNAc may play critical role(s) in cell interactions and tissue differentiations such as vasculogensis and angiogenesis as well as other developmental precursors in formation of the pituitary gland. |
|
| کلیدواژه‌های انگلیسی مقاله |
Angiogenesis, Glycoconjugates, Lectin, Pituitary, Rat |
|
| نویسندگان مقاله |
علیرضا ابراهیم زاده بیدسکان | ali reza ebrahimzadeh bideskan
department of anatomy, school of medicine, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
محمد مهدی حسن زاده طاهری | mohammad mehdi hassanzadeh taheri
department of anatomy, school of medicine, birjand university of medical sciences, birjand, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی بیرجند (Birjand university of medical sciences)
محمدرضا نیکروش | mohammad reza nikravesh
department of anatomy, school of medicine, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
علیرضا فاضل | ali reza fazel
department of anatomy, school of medicine, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
|
|
| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_4953.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45784.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Original Article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|