Iranian Journal of Basic Medical Sciences، جلد ۱۴، شماره ۲، صفحات ۱۵۸-۱۶۶

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عنوان انگلیسی Evaluation of Antioxidants in Bone Mineral Density of Iranian Osteoporotic Women
چکیده انگلیسی مقاله Objective(s) Bone is a dynamic tissue that is continuously renewed throughout life by the process of bone remodeling. Antioxidant system might be involved in the pathogenesis of bone loss, so the aim of this study was to evaluate the total antioxidant capacity (TAC), vitamin C and vitamin E levels of plasma besides measuring enzymatic antioxidants, superoxide dismutase (SOD), catalase (CAT) and glutathione reductase (GR) enzymes activity in Iranian osteoporotic women comparing to the control group. Materials and Methods Bone mineral density (BMD) of the femoral neck and lumbar spine was measured by dual x-ray absorptiometry. The participants were divided into groups: a) total participants (-3.9 ≤ T–score ≤ 3.6) including 192 women, b) the control group (T-score ≥ -1) including 76 women, c) the total patients (T-score < -1) including 76 women. Then, plasma TAC, vitamin C levels, SOD and GR activities, erythrocyte CAT were measured using spectrophotometrical methods separately, and for vitamin E by HPLC analysis. Results Comparing the control group and osteoporotic women showed that: a) plasma levels for vitamin C and erythrocyte CAT were markedly lower in the patients than in the controls, but plasma activity of TAC, SOD and GR were significantly higher, respectively. b) the differences were higher between control and patients with severe disease (T-score <-1.7) comparing to patients in the group with milder disease (-1.7 ≤ T-score <-1). c) Femoral neck BMD adjusted with age and BMI showed a positive and significant correlation with plasma levels of vitamin C in all subjects, but this relation was reverse or negative for TAC, SOD and GR. Conclusion It seems that a physiologic increase in the amount of some antioxidants occurs in osteoporosis; even though this amount may not be sufficient for the human body requirements.
کلیدواژه‌های انگلیسی مقاله Antioxidants, Blood, Bone density, Osteoporosis, Women

نویسندگان مقاله محمدرضا اویسی | mohammad reza oveisi
department of drug and food control, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نفیسه صادقی | naficeh sadeghi
department of drug and food control, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

بهروز جنت | behrooz jannat
food and drug laboratory research center, ministry of health and medical education, tehran, iran

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

منان حاجی محمودی | mannan hajimahmoodi
department of drug and food control, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

ملوک حاجی بابایی | molouk hadjibabaie
pharmacotherapy department, faculty of pharmacy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

عبدالعظیم بهفر | abdolazim behfar
drug and food control department, faculty of pharmacy, jondishapoor university of medical sciences, ahvaz, iran



نشانی اینترنتی http://ijbms.mums.ac.ir/article_4982.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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