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Iranian Journal of Basic Medical Sciences، جلد ۱۵، شماره ۲، صفحات ۷۳۹-۷۴۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The POLG Gene Polymorphism in Iranian Varicocele-Associated Infertility Patients |
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| چکیده انگلیسی مقاله |
Objective(s) Varicocele is associated with impaired testicular function and male infertility, but the molecular mechanisms by which fertility is affected have not been satisfactorily explained. The aim of our study was to investigate whether or not the polymerase gamma (POLG) polymorphism is associated with Iranian varicocele patients. Materials and Methods We determined the POLG CAG repeat length in DNA samples extracted from 40 varicocele patients and 30 control subjects by PCR-denature polyacrylamide gel electrophoresis and sequencing. Results The distribution of the CAG repeat length in varicocele patients showed no notable difference from that in control subjects, but we found a significant statistical inverse correlation between 10/10 and 10/#10 genotypes and varicocele grade. Conclusion These findings indicate that POLG CAG repeats may affects the varicocele grade, but the mechanisms remain to be elucidated. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
محمد مهدی حیدری | mohammad mehdi heidari
department of biology, science school, yazd university, yazd, iran
سازمان اصلی تایید شده: دانشگاه یزد (Yazd university)
مهری خاتمی | mehri khatami
department of biology, science school, yazd university, yazd, iran
سازمان اصلی تایید شده: دانشگاه یزد (Yazd university)
علیرضا طالبی | ali reza talebi
department of anatomy, research clinical center for infertility, shahid sadughi university of medical sciences, yazd, iran
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_4845.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45702.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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