|
|
Iranian Journal of Basic Medical Sciences، جلد ۱۵، شماره ۴، صفحات ۹۲۶-۹۳۶
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Effect of Cannabinoid Receptor Activation on Spreading Depression |
|
| چکیده انگلیسی مقاله |
Objective(s) The objective of this study was to evaluate the effect of cannabinoid on cortical spreading depression (CSD) in rat brain. Cannabis has been used for centuries for both symptomatic and prophylactic treatment of different types of headaches including migraine. CSD is believed to be a putative neuronal mechanism underlying migraine aura and subsequent pain. Materials and Methods The effects of Delta9-tetrahydrocannabinol (THC), as well as, cannabinoid CB1 and CB2 receptor agonists on CSD in rat neocortical slices were investigated. Furthermore, the effect of cannabinoid CB1 agonist was tested on field excitatory postsynaptic potentials (fEPSP) and long-term potentiation (LTP). Results HC (1-20 microM) dose dependently suppressed CSD amplitude, duration, and propagation velocity. Cannabinoid CB1 agonist, WIN 55,212-2 mesylate (1-10 microM), also significantly suppressed all characteristic features of CSD. However, cannabinoid CB2 agonist, JWH-133 (1-20 microM), did not affect CSD. FEPSP and induction of LTP were suppressed by application of WIN55212-2. Conclusion Suppression of CSD by activation of CB1 receptors points to the potential therapeutic effects of cannabinoids in migraine with aura. More research is needed before we know whether cannabinoids may be helpful in treating migraine pain. |
|
| کلیدواژه‌های انگلیسی مقاله |
|
|
| نویسندگان مقاله |
هادی کاظمی | hadi kazemi
shefa neuroscience research centre, tehran, iran|department of pediatrics, shahed university, tehran, iran
سازمان اصلی تایید شده: دانشگاه شاهد (Shahed university)
مهدی رهگذر | mehdi rahgozar
institut für physiologie i, westfalische wilhelms-universitat munster, münster, germany
erwin josef speckmann | erwin josef speckmann
institut für physiologie i, westfalische wilhelms-universitat munster, münster, german|institut für experimentelle epilepsieforschung, westfalische wilhelms-universitat munster, münster, germany
علی گرجی | ali gorji
institut für physiologie i, westfalische wilhelms-universitat munster, münster, germany
|
|
| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_4880.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45673.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Original Article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|