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Iranian Journal of Basic Medical Sciences، جلد ۱۵، شماره ۵، صفحات ۱۰۲۶-۱۰۳۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Study of Radioprotective Effect of Green Tea against Gamma Irradiation Using Micronucleus Assay on Binucleated Human Lymphocytes |
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| چکیده انگلیسی مقاله |
Objective(s)The aim of this study was to investigate the radioprotective effect of green tea against genotoxicity induced by gamma irradiation in cultured blood lymphocytes from 5 human volunteers.Materials and MethodsPeripheral blood samples were collected from volunteers before and 1, 3 and 5 hr after drinking a decoction 4 g green tea in 280 ml boiling water for 5 constitutive days with the same quantity. At each time point, the whole blood samples were exposed to 200 cGy of 60 Co gamma irradiation and then were cultured with mitogenic stimulation to determine the chromosomal aberration in micronucleus assay on cytokinesis-blocked binucleated cells.ResultsAs expected, for each volunteer, the results showed a significant increase in the incidence of micronuclei after exposure to gamma irradiation as compared to non-irradiated control samples. Only lymphocytes blood sample collected 3 hr after drinking green tea exhibited a significant decrease in incidence of micronuclei compared to non-treated irradiated samples.ConclusionThese results suggest the radioprotective ability of green tea against ionizing radiation in human lymphocytes, at specified time after consumptior. |
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| نویسندگان مقاله |
حافظه داوری | hafezeh davari
department of biology, faculty of sciences, ferdowsi university of mashhad, iran
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)
فرهنگ حداد | farhang haddad
department of biology, faculty of sciences, ferdowsi university of mashhad, iran
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)
علی مقیمی | ali moghimi
department of biology, faculty of sciences, ferdowsi university of mashhad, iran
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)
محمد فرهاد رحیمی | mohammad farhad rahimi
department of physics, faculty of sciences, ferdowsi university of mashhad, iran
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)
محمدرضا قوام نصیری | mohammad reza ghavamnasiri
cancer research centre crc , department of radiation oncology, omid hospital, mashhad university of medical science, mashhad, iran
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_4910.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45657.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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