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Iranian Journal of Basic Medical Sciences، جلد ۱۶، شماره ۶، صفحات ۷۵۱-۷۵۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Prevalence of PER and VEB Type Extended Spectrum Betalactamases among Multidrug Resistant Acinetobacter baumannii Isolates in North-West of Iran |
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| چکیده انگلیسی مقاله |
Objective(s): Drug resistant Acinetobacter baumannii have emerged as a major problem in many hospitals and intensive care units. Various types of extended spectrum beta-lactamases (ESBLs) are responsible for resistance to beta- lactam antibiotics in different parts of the world. The objective of this study was to determine the prevalence of integron class1 (INT 1) and ESBL types PER-1, PER-2 and VEB-1 among A. baumannii strains isolated from Tabriz, North-West of Iran. Material and Methods: A total of 100 A. baumannii isolates collected from different clinical samples were included in the study. Antimicrobial susceptibility profiles were determined using the Kirby Bauer disk diffusion method. Production of ESBL was investigated by testing resistance against ceftazidime, cefotaxime, ceftriaxone and verified by Double Disk Synergy Test. DNA was extracted from the isolates and the frequency of INT 1 and ESBL types PER-1, PER-2 and VEB-1 were determined by PCR using specific primers. Results: Among 100 A. baumannii isolates screened, 80 isolates were multidrug-resistant and 70 isolates were positive for ESBL production. PCR screening revealed that 74 % of the isolates contained class 1 integron, 51% were positive for PER-1 gene, 10% positive for VEB1 whereas none of the isolates were positive for PER2 type gene. Conclusion: This is the first report of ESBL types VEB and PER in A. baumannii from North West of Iran. The results of this study demonstrated high prevalence of PER-1 and VEB-1 type ESBLs among A. baumannii isolates in the study region and reminded the necessity of appropriate infection control strategy to prevent further spread of infection by these organisms. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
صفر فرج نیا | safar farajnia
drug applied research center, tabriz university of medical science, tabriz, iran
سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)
فاطمه اظهری | fatemeh azhari
biotechnology research center, tabriz university of medical science, tabriz, iran
سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)
محمد یوسف علیخانی | mohammad yousef alikhani
microbiology department, hamadan university of medical science, hamadan, iran
محمد کاظم حسینی | mohammad kazem hosseini
istanbul university, faculty of sciences, molecular biology and genetic, istanbul, turkey
امیر پیمانی | amir peymani
microbiology department, qazvin university of medical science, qazvin, iran
نصراله سهرابی | nasrolah sohrabi
paramedical faculty, kermanshah university of medical sciences, kermanshah, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمانشاه (Kermanshah university of medical sciences)
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_990.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45561.pdf |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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