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Iranian Journal of Basic Medical Sciences، جلد ۱۶، شماره ۸، صفحات ۹۲۲-۹۲۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Pentoxifylline Protects the Rat Liver Against Fibrosis and Apoptosis Induced by Acute Administration of 3,4-Methylenedioxymethamphetamine (MDMA or Ecstasy) |
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| چکیده انگلیسی مقاله |
Objective(s): 3,4-Methylenedioxymethamphetamine (MDMA) is one of the most popular drugs of abuse in the world with hallucinogenic properties that has been shown to induce apoptosis in liver cells. The present study aimed to investigate the effects of pentoxifylline (PTX) on liver damage induced by acute administration of MDMA in Wistar rat. Materials and Methods: Animals were administered with saline or MDMA (7.5 mg/kg, IP) 3 times with 2 hr intervals. PTX (200 mg kg, IP), was administered simultaneously with last injection of MDMA in experimental group. Results: The concomitant administration of pentoxifylline and MDMA decreased liver injury including apoptosis, fibrosis and hepatocytes damages. Conclusion: Our results showed for the first time that PTX treatment diminishes the extent of apoptosis and fibrosis caused by MDMA in rat liver. |
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| کلیدواژه‌های انگلیسی مقاله |
Apoptosis Fibrosis Liver MDMA Pentoxifylline |
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| نویسندگان مقاله |
شبنم موثقی | shabnam movassaghi
department of anatomy, islamic azad university tehran medical branch, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
زهرا نادیا شریفی | zahra nadia sharifi
department of anatomy, islamic azad university tehran medical branch, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
فرزانه محمدزاده | farzaneh mohammadzadeh
department of anatomy, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
منصوره سلیمانی | mansooreh soleimani
cellular and molecular research center, iran university of medical sciences, tehran, iran department of anatomy, iran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_1351.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45541.pdf |
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| زبان مقاله منتشر شده |
en |
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