Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۱، صفحات ۱۴-۲۰

عنوان فارسی
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عنوان انگلیسی Chitosan and polyvinyl alcohol composite films containing nitrofurazone: preparation and evaluation
چکیده انگلیسی مقاله Objective(s): The aim of this study was to insert nitrofurazone in a chitosan membrane to be used as a wound dressing. Materials and Methods: Several blend films using chitosan (Cs) and polyvinyl alcohol (PVA), containing nitrofurazone were prepared by means of casting/solvent evaporating technique. Different characteristics such as mechanical properties, water vapor transmission rate (WVTR), oxygen permeability (OP), swelling ability (SW), differential scanning calorimetric (DSC), drug release profiles and antibacterial activity of the films were investigated. Results: The results showed that nitrofurazone decreased tensile strength, OP and SW of Cs films, while increased WVTR. Addition of PVA at any concentration improved mechanical properties, reduced WVTR, and increased OP and SW of nitrofurazone-loaded Cs films. The latter films showed higher activity against Pseudomonas aeruginosa than drug-free chitosan films. Conclusion: The presence of PVA improves many properties of Cs-nitrofurazone films and makes them more desirable as dressing material for burn wounds. Although nitrofurazone alone is ineffective against P. aeruginosa, it is able to increase antibacterial effect of chitosan in composite films
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نویسندگان مقاله مریم کوچک | maryam kouchak
nanotechnology research center, ahvaz jundishapur university of medical sciences, ahvaz, iran 2 department of pharmaceutics, school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

عبدالغنی عامری | abdolghani ameri
microbiology research center, ahvaz jundishapur university of medical sciences, ahvaz, iran 4 department of food and drug control, school of pharmacy, ahvaz jundishapur university of medical sciences, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

بصیره ناصری | basireh naseri
1 nanotechnology research center, ahvaz jundishapur university of medical sciences, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)

سارا کارگر بلداجی | sara kargar boldaji
nanotechnology research center, ahvaz jundishapur university of medical sciences, ahvaz, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی جندی شاپور اهواز (Ahvaz jundishapur university of medical sciences)


نشانی اینترنتی http://ijbms.mums.ac.ir/article_2150.html
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کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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