| چکیده انگلیسی مقاله |
Objective(s): PCOS (polycystic ovary syndrome) produces symptoms in approximately 5% to 10% of women of reproductive age (12–45 years old). It is thought to be one of the leading causes of female subfertility. This study aimed to confirm the role of nutrition containing omega-3 (polyunsaturated fatty acid) on control of experimental PCO induced by estradiol-valerat in rats. Materials and Methods: Wistar female rats (n=40) were allocated into control (n=10) and test groups (n= 30), test group was subdivided into 3 groups: G1, received omega-3 (240 mg/kg/orally/daily); G2 and G3 groups were induced PCO by single injection of estradiol-valerate (16 mg/kg/IM). Group 3 received omega-3 (240 mg/kg/orally/daily) and low carbohydrate feeding for 60 subsequent days; on sixtieth day 5 ml blood samples and ovarian tissues of all rats in the group were removed and prepared for biochemical and hormonal analysis. Results: Catalase, GPX (Glutathione peroxidase), SOD (Superoxide dismutase) in groups that received omega-3showed higher levels, but MDA (malondialdehyde) level was significantly decreased (P< 0.05) in comparison with other experimental groups. Ovarian weights in both experimental and control groups were similar (P< 0.05). Level of serum FSH (follicle stimulating hormone) was decreased, but level of testosterone was significantly increased (P< 0.05) in PCO group in comparison with control and omega-3 groups. Conclusion: Results revealed that administration of omega-3 plus lower carbohydrate food significantly controlled PCO syndrome and balanced FSH and testosterone. |
| نویسندگان مقاله |
الهه ouladsahebmadarek | elaheh ouladsahebmadarek
women’s reproductive health research center, tabriz university of medical sciences, tabriz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
آرش خاکی | arash khaki
department of pathology, tabriz branch, islamic azad university, tabriz, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
شراره خان احمدی | sharareh khanahmadi
women’s reproductive health research center, tabriz university of medical sciences, tabriz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
حمیدرضا احمدی آشتیانی | hamidreza ahmadi ashtiani
department of biochemistry, islamic azad university, pharmaceutical, tehran, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
پویا پاک نژاد | pooya paknejad
women’s reproductive health research center, tabriz university of medical sciences, tabriz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
محمدرضا ایوبی | mohammad reza ayubi
department of pathology, tabriz branch, islamic azad university, tabriz, iran
سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)
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