Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۴، صفحات ۳۰۳-۳۱۱

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عنوان انگلیسی Evaluation of the effects of paederus beetle extract and gamma irradiation on HeLa cells
چکیده انگلیسی مقاله Objective(s):Cervical cancer is a malignancy that is the second most common cause of death from cancer in women throughout the world. Paederus beetle (Paederus fuscipes) extract (PBE), contains bioactive compounds such as pederine which has cytotoxic properties and blocks DNA and protein synthesis at very low concentrations. In this investigation we tried to determine the effects co-treatment with PBE and gamma irradiation on HeLa cells. Materials and Methods: The viability of the cells was measured by two methods: MTT and Colony assay. Results: We found that supplementing gamma irradiation therapy with PBE does not increase cell death and it might even interfere with its cytotoxicty at the concentrations below 0.1 ng/ml and the viability for irradiation vs irradiation + PBE was 37%: 60%. Conclusion: This finding might be due to radioprotective effects of the very low doses of PBE against gamma radiation.
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نویسندگان مقاله فریبا سامانی | fariba samani
cellular and molecular biology research center, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

علی شبستانی منفرد | ali shabestani monfared
cellular and molecular biology research center, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

ابراهیم ذبیحی | ebrahim zabihi
cellular and molecular biology research center, babol university of medical sciences, babol, iran 2 department of pharmacology amp;amp; physiology, school of medicine, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

ثریا خفری | soraya khafri
department of biostatistics, school of medicine, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)

معصومه کریمی | maesoumeh karimi
department of radiation therapy amp;amp; oncology, shahid rajaei hospital, babolsar, iran


هاله اخوان نیاکی | haleh akhavan niaki
cellular and molecular biology research center, babol university of medical sciences, babol, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بابل (Babol university of medical sciences)


نشانی اینترنتی http://ijbms.mums.ac.ir/article_2589.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45448.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short Communications
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