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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۵، صفحات ۳۳۲-۳۳۶
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Glutathione s-transferase M1 and T1 genetic polymorphisms in Iranian patients with glaucoma |
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| چکیده انگلیسی مقاله |
Objective(s):Glaucoma is the second leading cause of blindness and it is related to oxidative stress based on numerous studies. Glutathione S-transferases (GSTs) are members of multigenic family, which have important role in cells as an antioxidant. In the present study, we examined the polymorphism of GSTT1 and GSTM1 deletion genotypes (T0M1, T1M0, and T0M0) in 100 Glaucoma patients (41with primary open angle glaucoma (PCAG), and 59 with primary closed angle glaucoma (POAG)) compared to 100 healthy subjects. Materials and Methods: GSTM1and GSTT1 polymorphisms were determined by multiplex polymerase chain reaction. Results: GSTM1 and GSTT1 null deletions genotypes were determined in 22 (53.7%) and 7 (17.1%) patients with PCAG and 34 (34%) and 15 (15%) in healthy subjects[VAIO1] . Comparison between patients and healthy subjects regarding GSTM1 and GSTT1 genotypes revealed increase of GSTM1 null deletions genotypes in patients with PCAG (P=0.03). Conclusion: It was concluded that the increased frequencies of GSTM1 null in patients with PCAG could be a risk factor for incidence of PCAG in the Iranian population. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
فاطمه کاظمی صفا | fatemeh kazemi safa
department of health, kermanshah university medical of sciences, kermanshah, iran
غلامرضا شهسواری | gholamreza shahsavari
lorestan university medical of sciences, khoram abad, iran
سازمان اصلی تایید شده: دانشگاه لرستان (Lorestan university)
رضا زارع ابیانه | reza zare abyaneh
tehran university medical of sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_2782.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45429.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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