|
|
Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۱۱، صفحات ۸۷۴-۸۷۸
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Expressions of CD11a, CD11b, and CD11c integrin proteins in rats with myocardial hypertrophy |
|
| چکیده انگلیسی مقاله |
Objective(s):To examine the expressions of CD11a, CD11b, and CD11c integrins in the myocardial tissues of rats with isoproterenol-induced myocardial hypertrophy. This study also provided morphological data to investigate the signal transduction mechanisms of myocardial hypertrophy and reverse it. Materials and Methods: A myocardial hypertrophy model was established by subcutaneously injecting isoprenaline in healthy adult Sprague-Dawley rats. Myocardial tissues were obtained, embedded in conventional paraffin, sectioned, and stained with hematoxylin. Pathological changes in myocardial tissues were then observed. The expressions and distributions of CD11a, CD11b, and CD11c integrins were detected by immunohistochemistry. Changes in the mRNA expressions of CD11a, CD11b, and CD11c in the myocardial tissues of rats were detected by RT-PCR. Image analysis software was used to determine the expressions of CD11a, CD11b, and CD11c integrins quantitatively. Results: Immunohistochemical results showed that the positive expressions of CD11a, CD11b, and CD11c integrins increased significantly in the experimental group compared with those in the control group. The mRNA expressions of CD11a, CD11b, and CD11c in the myocardial tissues of rats were consistent with the immunohistochemical results. Conclusion: The increase in the protein expressions of CD11a, CD11b, and CD11c integrins may have an important role in the occurrence and development of myocardial hypertrophy. |
|
| کلیدواژه‌های انگلیسی مقاله |
CD11a, CD11b, CD11c, Integrin, Myocardial hypertrophy, Rat |
|
| نویسندگان مقاله |
lingmin mu | lingmin mu
morphological laboratory of xinxiang medical university, xinxiang, henan 453003, p. r. china
changqin جینگ | changqin jing
life science and technology department, xinxiang medical university, xinxiang, henan 453003, p. r. china
zhikun گیو | zhikun guo
key open laboratory for tissue regeneration of henan providence, xinxiang, henan 453003, p. r. china
|
|
| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_3738.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45349.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
Original Article |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|