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Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۱۲، صفحات ۱۰۱۲-۱۰۳۵
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Thymoquinone, the main constituent of Nigella sativa, affects adenosine receptors in asthmatic guinea pigs |
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| چکیده انگلیسی مقاله |
Objective(s): For determining the mechanism of anti-asthmatic effect of thymoquinone, this investigation evaluated the effect of thymoquinone in the presence of selective A2A and A2B adenosine receptor antagonists (ZM241385 and MRS1706, respectively). Materials and Methods: Seventy guinea pigs were randomly divided to 7 groups; control (C), sensitized with ovalbumin (S), sensitized groups pretreated with thymoquinone (S+TQ), ZM241385 (S+Anta A2A), MRS1706 (S+Anta A2B), thymoquinone and antagonists (S+Anta A2A+TQ and S+Anta A2B+TQ). Thymoquinone and each of these antagonists with 3 mg/kg dose were injected i.p. on 10th day of sensitization protocol. Tracheal responsiveness (TR) to methacholine and ovalbumin (OA), and total and differential cell count in lung lavage fluid (LLF) in different groups were measured. Results: Increased EC50 and LLF neutrophil count and decreased TR to methacholine and OA, LLF eosinophil and basophil counts were observed in S+TQ group compared to S group (PP< 0.05). Significant decrease in EC50 (P< 0.01), LLF neutrophil, lymphocyte and monocyte count (PP< 0.01), LLF total WBC (P< 0.01) and eosinophil count (P< 0.001) were observed in S+A2A group compared to S+TQ group. There was significant increase in LLF eosinophil and monocyte counts in S+Anta A2B group compared with S+TQ group (P2A group, there was significant increase in LLF eosinophil (P< 0.001) and significant decrease in LLF neutrophil (P< 0.01) and monocyte (P< 0.001) counts compared with S+TQ group. Conclusion: Thymoquinone affects adenosine receptors, which suggest that some of its anti-inflammatory effects may be mediated by these receptors. |
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| کلیدواژه‌های انگلیسی مقاله |
Asthma, Adenosine receptor, MRS1706, Thymoquinone, ZM241385 |
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| نویسندگان مقاله |
لاله پژمان | laleh pejman
department of physiology, faculty of medicine, tabriz university of medical sciences, tabriz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
حسن عمرانی | hasan omrani
department of physiology, faculty of medicine, tabriz university of medical sciences, tabriz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
زهرا میرزامحمدی | zahra mirzamohammadi
department of physiology, faculty of medicine, tabriz university of medical sciences, tabriz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
رعنا کیهان منش | rana keyhanmanesh
tuberculosis and lung diseases research center, tabriz university of medical sciences, tabriz, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_3861.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45339.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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