Iranian Journal of Basic Medical Sciences، جلد ۱۷، شماره ۱۲، صفحات ۱۰۰۱-۱۰۰۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی In vitro lethal effects of various extracts of Nigella sativa seed on hydatid cyst protoscoleces
چکیده انگلیسی مقاله Objective(s): There are several scolicidal agents for inactivation of hydatid cyst protoscolices during surgery, but most of them are associated with adverse side effects such as sclerosing cholangitis and liver necrosis. The present study was aimed to evaluate scolicidal effects of various extracts of Nigella sativa seeds againstprotoscoleces of hydatid cyst in an in vitro model. Materials and Methods: Protoscoleces were aseptically aspirated from naturally infected livers of sheep and goats. Various concentrations of the different extracts of N. sativa (5 to 50 mg/ml) were used for 5 to 60 min. Viability of protoscoleces was confirmed by 0.1% eosin staining. Results: The findings exhibited that methanolic extract at the concentration of 50 mg/ml after 10 min of incubation, and aqueous extract at the concentration of 50 mg/ml after 30 min of incubation can kill 100% of protoscoleces. In addition, all of experiments revealed dose-dependent and also time-dependent scolicidal effect of various extracts of N. sativa on the protoscoleces of hydatid cyst. Conclusion: The results of the present study demonstrated that N. sativa may be a natural source for the production of new scolicidal agent for use in hydatid cyst surgery. However, further studies will be required to evaluate scolicidal effects of N. sativa in the in vivo model.
کلیدواژه‌های انگلیسی مقاله hydatid cyst, Echinococcus Granulosus, Nigella sativa
نویسندگان مقاله حسین محمودوند | hossein mahmoudvand
research center for tropical and infectious diseases, kerman university of medical science, kerman, iran research center for hydatid disease in iran, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

آرش اسدی | arash asadi
department of medical parasitology and mycology, kerman university of medical sciences kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

مجید فصیحی هرندی | majid fasihi harandi
research center for hydatid disease in iran, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

فریبا شریفی فر | fariba sharififar
department of pharmacognosy, faculty of pharmacy, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

ساره جهانبخش | sareh jahanbakhsh
research center for tropical and infectious diseases, kerman university of medical science, kerman, iran research center for hydatid disease in iran, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

ebrahimm ساعدی دزکی | ebrahimm saedi dezaki
research center for hydatid disease in iran, kerman university of medical sciences, kerman, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_3859.html
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کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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