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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۴، صفحات ۳۱۲-۳۱۶
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عنوان فارسی |
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چکیده فارسی مقاله |
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کلیدواژههای فارسی مقاله |
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عنوان انگلیسی |
The frequency of CCR5 promoter polymorphisms and CCR5 32 mutation in Iranian populations |
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چکیده انگلیسی مقاله |
Evidence showed that chemokines serve as pro-migratory factors for immune cells. CCL3, CCL4 and CCL5, as the main CC chemokines subfamily members, activate immune cells through binding to CC chemokine receptor 5 or CCR5. Macrophages, NK cells and T lymphocytes express CCR5 and thus, affected CCR5 expression or functions could be associated with altered immune responses. Deletion of 32 base pairs (D 32) in the exon 1 of the CCR5 gene, which is known as CCR5 D 32 mutation causes down regulation and malfunction of the molecule. Furthermore, it has been evidenced that three polymorphisms in the promoter region of CCR5 modulate its expression. Altered CCR5 expression in microbial infection and immune related diseases have been reported by several researchers but the role of CCR5 promoter polymorphisms and CCR5 D 32 mutation in Iranian patients suffering from these diseases are controversial. Due to the fact that Iranian people have different genetic backgrounds compared to other ethnics, hence, CCR5 promoter polymorphisms and CCR5 D 32 mutation association with the diseases may be different in Iranian patients. Therefore, this review addresses the most recent information regarding the prevalence as well as association of the mutation and polymorphisms in Iranian patients with microbial infection and immune related diseases as along with normal population. |
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کلیدواژههای انگلیسی مقاله |
CCR5, 32 mutation, Polymorphism, Iran |
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نویسندگان مقاله |
محمد زارع بیدکی | mohammad zare bidaki immunology of infectious diseases research center, rafsanjan university of medical sciences, rafsanjan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)
مسعود کریمی googheri | masoud karimi googheri department of immunology, faculty of medicine, kerman university of medical sciences, kerman, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
غلامحسین حسن شاهی | gholamhossein hassanshahi molecular medicine research center, rafsanjan university of medical sciences, rafsanjan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)
ناهید زین الدینی | nahid zainodini immunology of infectious diseases research center, rafsanjan university of medical sciences, rafsanjan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)
محمد کاظمی عرب آبادی | mohammad kazemi arababadi immunology of infectious diseases research center, rafsanjan university of medical sciences, rafsanjan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی رفسنجان (Rafsanjan university of medical sciences)
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نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_4278.html |
فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45267.pdf |
کد مقاله (doi) |
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زبان مقاله منتشر شده |
en |
موضوعات مقاله منتشر شده |
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نوع مقاله منتشر شده |
Review Article |
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