Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۵، صفحات ۵۲۰-۵۲۵
عنوان فارسی
چکیده فارسی مقاله
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عنوان انگلیسی The effect of intrathecal delivery of bone marrow stromal cells on hippocampal neurons in rat model of Alzheimer’s disease
چکیده انگلیسی مقاله Objective(s): Intracerebral injection of bone marrow stromal cells (BMSCs) is being investigated as a therapeutic tool to prevent Alzheimer's disease (AD). Our aim was to investigate the effects of BMSCs by intrathecal injection in AD rat model. Materials and Methods: BMSCs were obtained from the bone marrow of Wistar rat and transplanted into AD rat model via intrathecal injection. The rat model had received an injection of β amyloid into the hippocampus for histological and immunohistochemical studies. Results: Histological examination of the brains in transplanted rats compared to controls demonstrated the migration of BrdU-labeled BMSCs from the site of delivery, confirmed the differentiation of BMSCs transplanted cells into the cholinergic neurons, and increased number of healthy and decreased number of dark neurons. Conclusion: Our results showed that BMSCs intratechal administration could be a promising method for treatment ofAlzheimer’s disease in rat model.
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نویسندگان مقاله مینا افتخارزاده | mina eftekharzadeh
department of anatomy, faculty of medicine, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

ملیحه نوبخت | maliheh nobakht
department of anatomy, faculty of medicine, iran university of medical sciences, tehran, iran|cellular and molecular research center, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

اکرم علیزاده | akram alizadeh
department of tissue engineering, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

منصوره سلیمانی | mansooreh soleimani
department of anatomy, faculty of medicine, iran university of medical sciences, tehran, iran|cellular and molecular research center, iran university of medical sciences, tehran, iran|department of medical genetics and molecular biology, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

محمود حاج قاسم | mahmood hajghasem
department of neuroscience, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

بهاره کردستانی شرق | bahareh kordestani shargh
department of basic sciences, faculty of allied medicine, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نوشین karkuki osguei | nushin karkuki osguei
eposcience millennium institute, tehran, iran


بابک بهنام | babak behnam
cellular and molecular research center, iran university of medical sciences, tehran, iran|department of medical genetics and molecular biology, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

علی صمدی کوچکسرایی | ali samadikuchaksaraei
cellular and molecular research center, iran university of medical sciences, tehran, iran|department of tissue engineering and regenerative medicine, faculty of advanced technologies in medicine, iran university of medical sciences, tehran, iran|department of medical biotechnology, faculty of allied medicine, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_4417.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45265.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Short Communications
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