Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۶، صفحات ۶۲۳-۶۲۶

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عنوان انگلیسی Association between mutations in gyrA and parC genes of Acinetobacter baumannii clinical isolates and ciprofloxacin resistance
چکیده انگلیسی مقاله Objective(s): We investigated the contribution of gyrA and parC mutational mechanism in decreased ciprofloxacin susceptibility of Acinetobacter baumannii isolated from burn wound infections. Materials and Methods: Ciprofloxacin susceptibility of 50 A. baumannii isolates was evaluated by disk diffusion and agar dilution methods. PCR and sequencing were performed for detection of mutation in gyrA and parC genes. Results: The 44 and 4 isolates of A. baumannii exhibited full and intermediate-resistant to ciprofloxacin, respectively. Overall, the 42 isolates with double mutations of gyrA and parC genes showed a higher level of ciprofloxacin resistance than the 3 isolates with single mutations of gyrA or parC. Conclusion: Simultaneous mutations in gyrA and parC genes are expected to play a major role in high-level fluoroquinolone resistance in A. baumannii; albeit a single mutation in DNA topoisomerase IV could occasionally be associated with intermediate-resistance to these antimicrobials.
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نویسندگان مقاله عبدالله اردبیلی | abdollah ardebili
department of microbiology, faculty of medicine, golestan university of medical sciences, gorgan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی گلستان (Golestan university of medical sciences)

عبدالعزیز رستگار لاری | abdolaziz rastegar lari
department of microbiology, faculty of medicine, iran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

مریم بهشتی | maryam beheshti
department of microbiology, faculty of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

الناز رستگار لاری | elnaz rastegar lari
department of science and environment, faculty of science, technology and communication, luxembourg university and faculty of science and environment university of liege, liege, belgium



نشانی اینترنتی http://ijbms.mums.ac.ir/article_4543.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Short Communications
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