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Iranian Journal of Basic Medical Sciences، جلد ۱۸، شماره ۱۲، صفحات ۱۲۲۸-۱۲۳۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Case-control study on peroxisome proliferator-activated receptor gamma polymorphism and interaction with HDL on essential hypertension in Chinese Han |
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| چکیده انگلیسی مقاله |
Objective(s): To investigate the association of single nucleotide polymorphisms (SNPs) in the peroxisome proliferator-activated receptors gamma (PPARG) with essential hypertension (EH) and additional role of gene– high-density lipoprotein cholesterol (HDL) interaction. Materials and Methods:A total of 1640 patients with EH (806 males, 834 females), with a mean age of 52.5±12.6 years, were selected, including 816 EH patients and 824 controls, who were enrolled from the community. Three SNPs were selected for genotyping in the case–control study: rs10865710, rs709158, rs1805192. Logistic regression model was used to examine the interaction between SNP and HDL on EH, odds ratio (OR) and 95% confidence interval (95% CI) were also calculated. Results: All genotypes were distributed according to Hardy–Weinberg equilibrium in controls. Logistic regression analysis showed an association between genotypes of variants in rs1805192 and decreased EH risk, EH risk was significantly lower in carriers of Ala allele of the rs1805192 polymorphism than those with Pro/Pro (Pro/Ala+ Ala/Ala versus Pro/Pro, adjusted OR (95% CI) =0.65 (0.53–0.83), after covariate adjustment. In addition, the Ala allele of the rs1805192 polymorphism was also associated with diastolic blood pressure (DBP), but not systolic blood pressure (SBP), we also found, by interaction analysis, combined effect of rs1805192 and HDL on EH risk after covariate adjustment. Conclusion: Our results support an important association between rs1805192 minor allele (Ala allele) of PPARG and lower EH risk, the interaction analysis showed a combined effect of Ala- HDL on lower EH risk. |
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| نویسندگان مقاله |
gang ونگ | gang wang
department of cardiac surgery, the affiliated hospital of qingdao university, qingdao 266003, china
ping xu | ping xu
department of cardiac surgery, the affiliated hospital of qingdao university, qingdao 266003, china
wei feng | wei feng
department of cardiac surgery, beijing fuwai hospital, beijing 100037, china
xianyan jiang | xianyan jiang
department of cardiac surgery, qingdao fuwai hospital, qingdao 266034, china
تایو زانگ | tao zhang
department of cardiac surgery, qingdao fuwai hospital, qingdao 266034, china
ژیان li | jian li
department of cardiac surgery, qingdao fuwai hospital, qingdao 266034, china
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_6276.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45154.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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