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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۳، صفحات ۲۳۸-۲۴۴
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عنوان فارسی |
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چکیده فارسی مقاله |
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کلیدواژههای فارسی مقاله |
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عنوان انگلیسی |
The role of nitric oxide on the oxytocin induce analgesia in mice |
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چکیده انگلیسی مقاله |
Objective(s): Analgesic effects of oxytocin and it's the other physiological effects were well-known. The aim of present study was determination of nitric oxide role on analgesic effects of oxytocin in mice. Materials and Methods: 216 male Albino mice were divided randomly into two experimental groups, tail flick and formalin test. Each experimental group consists of three main groups including: saline, L-arginine (50 mg/kg) and L-NAME (10 mg/kg) intraperitoneal (IP) injection. 15 min after injection in each of the following groups, the animals in each groups divided to the three subgroups including: saline (n=12), oxytocin (1 mg/kg) (n=12) and oxytocin (1 mg/kg) + atosiban (1 mg/kg) (n=12) was injected IP and then after 30 min of use the formalin test and tail flick were to evaluate the response to pain. Results: Area under the curve (AUC) in the late phase of the formalin test, in sub-groups oxytocin + saline and L-NAME were significantly decreased compared with saline + saline group (P< 0.05 to P< 0.001), and AUC in L-arginine + saline and atosiban + saline + oxytocin were significantly increased compared with oxytocin + saline group (P< 0.05). Tail flick tests as well as a significant reduction in the AUC in oxytocin + L-arginine and atosiban + saline + oxytocin groups were compared with Oxytocin + Saline group (P<0.001). Conclusion: Oxytocin has analgesic effects in the acute and late phase of pain in the formalin test. Moreover, exogenous increasing of nitric oxide reduced the analgesic effect of oxytocin. |
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کلیدواژههای انگلیسی مقاله |
analgesia, Mice, Nitric Oxide, Oxytocin |
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نویسندگان مقاله |
عباسعلی عباس نژاد | abbasali abbasnezhad department of basic sciences, faculty of medicine, gonabad university of medical sciences, gonabad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی گناباد (Gonabad university of medical sciences)
محمدرضا خزدیر | mohammad reza khazdair pharmaceutical research center and department of physiology, school of medicine, mashhad, iran|student research committee, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
مجید کیان مهر | majid kianmehr department of physiology, school of medicine, mashhad university of medical sciences, mashhad, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)
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نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_6641.html |
فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45100.pdf |
کد مقاله (doi) |
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زبان مقاله منتشر شده |
en |
موضوعات مقاله منتشر شده |
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نوع مقاله منتشر شده |
Original Article |
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