Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۵، صفحات ۵۲۱-۵۲۸

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عنوان انگلیسی Difference in transient ischemia-induced neuronal damage and glucose transporter-1 immunoreactivity in the hippocampus between adult and young gerbils
چکیده انگلیسی مقاله Objective(s): The alteration of glucose transporters is closely related with the pathogenesis of brain edema. We compared neuronal damage/death in the hippocampus between adult and young gerbils following transient cerebral ischemia/reperfusion and changes of glucose transporter-1(GLUT-1)-immunoreactive microvessels in their ischemic hippocampal CA1 region. Materials and Methods: Transient cerebral ischemia was developed by 5-min occlusion of both common carotid arteries. Neuronal damage was examined by cresyl violet staining, NeuN immunohistochemistry and Fluoro-Jade B histofluorescence staining and changes in GLUT-1 expression was carried out by immunohistochemistry. Results: About 90% of pyramidal neurons only in the adult CA1 region were damaged after ischemia/reperfusion; in the young, about 53 % of pyramidal neurons were damaged from 7 days after ischemia/reperfusion. The density of GLUT-1-immunoreactive microvessels was significantly higher in the young sham-group than that in the adult sham-group. In the ischemia-operated-groups, the density of GLUT-1-immunoreactive microvessels was significantly decreased in the adult and young at 1 and 4 days post-ischemia, respectively, thereafter, the density of GLUT-1-immunoreactive microvessels was gradually increased in both groups after ischemia/reperfusion. Conclusion: CA1 pyramidal neurons of the young gerbil were damaged much later than that in the adult and that GLUT-1-immunoreactive microvessels were significantly decreased later in the young. These data indicate that GLUT-1 might differently contribute to neuronal damage according to age after ischemic insults.
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نویسندگان مقاله seung امین سونگ گو | seung min park
department of emergency medicine, school of medicine, kangwon national university, chuncheon 200-701, south korea|department of emergency medicine, sacred heart hospital, college of medicine, hallym university, anyang431-796, south korea


jae chul lee | jae chul lee
department of neurobiology, school of medicine, kangwon national university, chuncheon 200-701, south korea


بای هیو chen | bai hui chen
department of physiology, college of medicine, hallym university, chuncheon 200-702, south korea


bich na shin | bich na shin
department of physiology, college of medicine, hallym university, chuncheon 200-702, south korea


jeong hwi cho | jeong hwi cho
department of neurobiology, school of medicine, kangwon national university, chuncheon 200-701, south korea


in hye کیم | in hye kim
department of neurobiology, school of medicine, kangwon national university, chuncheon 200-701, south korea


جون ha سونگ گو | joon ha park
department of neurobiology, school of medicine, kangwon national university, chuncheon 200-701, south korea


محمدناصر ho won | moo ho won
department of neurobiology, school of medicine, kangwon national university, chuncheon 200-701, south korea


ji hyeon ahn | ji hyeon ahn
department of biomedical science, research institute of bioscience and biotechnology, hallym university, chuncheon 200-702, south korea


hyun جین tae | hyun jin tae
department of biomedical science, research institute of bioscience and biotechnology, hallym university, chuncheon 200-702, south korea


myoung cheol shin | myoung cheol shin
department of emergency medicine, school of medicine, kangwon national university, chuncheon 200-701, south korea


چان woo سونگ گو | chan woo park
department of emergency medicine, school of medicine, kangwon national university, chuncheon 200-701, south korea


جون hwi cho | jun hwi cho
department of emergency medicine, school of medicine, kangwon national university, chuncheon 200-701, south korea


هیو یانگ lee | hui young lee
department of internal medicine, school of medicine, kangwon national university, chuncheon 200-701, south korea



نشانی اینترنتی http://ijbms.mums.ac.ir/article_6937.html
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