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Iranian Journal of Basic Medical Sciences، جلد ۱۹، شماره ۹، صفحات ۹۵۳-۹۵۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Inactivated Mycobacterium phlei inhalation ameliorates allergic asthma through modulating the balance of CD4+CD25+ regulatory T and Th17 cells in mice |
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| چکیده انگلیسی مقاله |
Objective(s): Th2 response is related to the aetiology of asthma, but the underlying mechanism is unclear. To address this point, the effect of nebulized inhalation of inactivated Mycobacterium phlei on modulation of asthmatic airway inflammation was investigated. Materials and Methods: 24 male BALB/c mice were randomly divided into three groups: control group (Group A), asthma model group (Group B), and the medicated asthma model group (Group C). Group B and C were sensitized and challenged with ovalbumin (OVA). Group C was treated with aerosol M. phlei once daily before OVA challenge. Airway responsiveness in each group was assessed. All the animals were killed, and lung tissues and bronchoalveolar lavage fluid (BALF) were harvested. Inflammatory response, proportion of Th17 and CD4+CD25+ Treg cells, and the levels of cytokines were analyzed in lung tissue. Results: The proportion of Th17 cells and expression level of IL17, IL23, and IL23R were increased, while Foxp3 expression was decreased in Group B. Inhaling inactivated M. phlei inhibited airway inflammation and improved airway hyper-responsiveness, as well as peak expiratory flow (PEF). In addition, it significantly increased Th17 proportion, Foxp3 level, and the proportion of CD4+CD25+ Treg cells in lung tissue in Group C. Conclusion: Inactivated M. phlei was administered by atomization that suppressed airway inflammation and airway hyper responsiveness partially via modulating the balance of CD4+CD25+ regulatory T and Th17 cells. |
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| نویسندگان مقاله |
moyu ming | moyu ming
department of respiratory medicine, the first affiliated hospital of guangxi medical university, nanning, guangxi, china 530021
zhixi luo | zhixi luo
department of respiratory medicine, the first affiliated hospital of guangxi medical university, nanning, guangxi, china 530021
shengqiu lv | shengqiu lv
department of respiratory medicine, the first affiliated hospital of guangxi medical university, nanning, guangxi, china 530021
qixiang سون | qixiang sun
department of respiratory medicine, the first affiliated hospital of guangxi medical university, nanning, guangxi, china 530021
chaoqian li | chaoqian li
department of respiratory medicine, the first affiliated hospital of guangxi medical university, nanning, guangxi, china 530021
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| نشانی اینترنتی |
http://ijbms.mums.ac.ir/article_7595.html |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-45014.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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