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Journal of Kerman University of Medical Sciences، جلد ۵، شماره ۳، صفحات ۱۰۳-۱۰۹
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Synthesis of new piperazinyl quinolones and investigation of their in vitro antibacterial activities |
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| چکیده انگلیسی مقاله |
Quinolone antibacterial agents are currently used for the treatment of various bacterial infections. The nature of functional group at the 7 position of the quinolone ring system is known to have strong influence on the spectrum and extent of in vitro antibacterial activity. Accordingly, a series of N-L2- oxo-2-(2- furyl) and N-[2- oxyimino (2- furyl) ethyl] piperazinyl quinolone derivatives were synthesized and evaluated for in vitro antibacterial activity. Compounds having 2- oxo-2-(-2 furyl) ethyl group attached to the piperazine ring were as potent as norfloxacin and ciprofloxacin. The oximes were more active than corresponding ketones and original quinolone s against gram positive bacteria but less active against gram negative bacteria. The methyl oximes and O- benzyloximes were almost a potent as the corresponding quinolones against gram positive bacteria but less active against gram negative bacteria. |
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| کلیدواژه‌های انگلیسی مقاله |
synthesis, quinolones, Antibacterial activity |
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| نویسندگان مقاله |
علیرضا foromandi | a r
assistant professor
p حقیقت |
s امامی |
محمدحسین moshefi | m h
assistant professor
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| نشانی اینترنتی |
http://jkmu.kmu.ac.ir/article_34304_fbc27c95c24b89bab149c47459f926a5.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/93/article-93-405487.pdf |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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