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Journal of Kerman University of Medical Sciences، جلد ۱۵، شماره ۱، صفحات ۱-۱۱
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
The Expression of P53 in Leukoplakia, Squamous Cell Carcinoma and Normal Oral Epithelium Using Immunohistochemical Staining Method |
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| چکیده انگلیسی مقاله |
Background & Aims: Leukoplakia is the most common premalignant or potentially malignant lesion of the oral mucosa and its potentiality for malignant transformation is unpredictable. The aim of the present study was to evaluate p53 expression in normal oral epithelium, leukoplakia and oral squamous cell carcinoma. Methods: The standard Biotin streptavaidin peroxidase immunohistochemical staining method was used to study the expression of p53 on formalin fixed, paraffin embedded blocks of 8 cases of squamous cell carcinoma, 20 cases of leukoplakia and 10 cases of normal oral epithelium. Results: There was no significant difference between immunostaining of leukoplakia and normal epithelium groups in the expression of P53, but the distribution patterns of p53 was mainly localized in the basal layer in the group of normal oral mucosa, while it extended into the suprabasal cell layer in leukoplakia group. P53 expression in squamous cell carcinoma group was higher than other groups. Conclusion: Considering the findings the expression of p53 in suprabasal cell layers in leukoplakia might show poor clinical outcome and alterations of p53 might be an important factor in the development of oral cancer. |
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| نویسندگان مقاله |
sh ادهمی |
assistant professor of oral pathology, school of dentistry, kerman university of medical sciences, kerman, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
f بقایی |
assistant professor of oral pathology, school of dentistry, hamadan university of medical sciences, hamadan, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی همدان (Hamadan university of medical sciences)
sh کاکویی |
assistant professor of oral medicine, school of dentistry, kerman university of medical sciences, kerman, iran.
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
m ریوف |
assistant professor of endodontics, school of dentistry, kerman university of medical sciences, kerman, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی کرمان (Kerman university of medical sciences)
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| نشانی اینترنتی |
http://jkmu.kmu.ac.ir/article_17309_97eed2a99730e3cf8621f4e49afa0e84.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/93/article-93-405163.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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