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Journal of Kerman University of Medical Sciences، جلد ۲۳، شماره ۴، صفحات ۵۱۵-۵۴۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
A Glance into Cancer Stem Cells |
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| چکیده انگلیسی مقاله |
The presence of stem cells in leukemia and solid tumors has been demonstrated in recent decades. Cancer stem cells have the potency of tumorigenesis; furthermore, they have the ability of self-renewing and differentiation like other stem cells. They also play important role in the process of tumor invasion and metastasis. Several studies have been performed to discover the specific markers and different phenotypes of these cells that can be very important in their identification. It seems that the characteristic of cancer stem cells, like tumor genesis, is greatly related to the specific signaling pathways such as Wnt, β catenin and hedgehog. In addition, the tumor microenvironment and its controlling agents are the important factors involving in the regulation of cancer stem cell function. The present review aimed to investigate the biology of cancer stem cells, specific signaling pathways, factors controlling the microenvironment as well as the role of microRNAs in controlling the function of these cells to provide new therapeutic methods. |
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| کلیدواژه‌های انگلیسی مقاله |
stem cell, Cancer, Review study |
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| نویسندگان مقاله |
حمید خدایاری |
cancer research center, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
ریحانه چمنی |
ph.d. in biochemistry, cancer research center, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
سعید خدایاری |
cancer research center, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
علی محمد علیزاده | ali mohammad
assistant professor of medical physiology, cancer research center, tehran university of medical sciences, tehran, iran
سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)
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| نشانی اینترنتی |
http://jkmu.kmu.ac.ir/article_16638_1f76daa463d309288d3c0f057c17da1f.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/93/article-93-404779.pdf |
| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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