Journal of Kerman University of Medical Sciences، جلد ۲۳، شماره ۶، صفحات ۷۹۷-۸۲۸

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عنوان انگلیسی Spermatogonial Stem Cells: Biology, Isolation, Culture, Characterization, and Practical Perspectives
چکیده انگلیسی مقاله Spermatogonial stem cells (SSCs) also known as germ stem cells (GSCs) are the basis of spermatogenesis process in the testis. Furthermore, they are also valuable cells with different applications in developmental biology, transgenesis technology, and clinic. Understanding the new findings related to the cell and molecular biology of SSCs and the methods for isolation and maintenance of these cells are important and essential for their applications in medicine to treat some infertility problems and also in biotechnology to produce transgenic animals. The present review was conducted to describe the cell and molecular basis of development, self-renewal, and differentiation of mammalian and poultry SSCs in vivo (natural niche) and in vitro. Moreover, this study represents specific molecular markers to characterize SSCs. We also introduce methods to isolate, cultivate and enrich these cells, which are important for their applications. Finally, the significance of SSCs in different fields and their practical perspectives, and also the differentiation potential of other stem cells into spermatogonial- and spermatic-like cells are discussed.
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نویسندگان مقاله سجاد سی سخت نژاد |
assistant professor, department of biology, faculty of science, razi university, kermanshah, iran
سازمان اصلی تایید شده: دانشگاه رازی (Razi university)

احمدرضا بهرامی | ahmad reza
professor, department of biology, faculty of science amp; institute of biotechnology, ferdowsi university of mashhad, mashhad, iran
سازمان اصلی تایید شده: دانشگاه رازی (Razi university)

مریم مقدم متین | moghadam matin
professor, department of biology, faculty of science amp; institute of biotechnology, ferdowsi university of mashhad, mashhad, iran
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

فاطمه بهنام رسولی | behnam rassouli
assistant professor, department of biology, faculty of science amp; institute of biotechnology, ferdowsi university of mashhad, mashhad, iran
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

مجید مومنی مقدم | momeni moghadam
assistant professor, department of biology, faculty of science, hakim sabzevari university, sabzevar, iran
سازمان اصلی تایید شده: دانشگاه فردوسی (Ferdowsi university)

سهراب بوذرپور |
assistant professor, department of biology, faculty of basic science, gonbad kavous university, gonbad kavous, iran
سازمان اصلی تایید شده: دانشگاه حکیم سبزواری (Hakim sabzevari university)


نشانی اینترنتی http://jkmu.kmu.ac.ir/article_41283_7bbd1cfe37bd275a95b86b38fc5208e4.pdf
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/93/article-93-404759.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده 3
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