Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۲، صفحات ۱۳۸-۱۴۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Exploring the effect of intravenous lipid emulsion in acute methamphetamine toxicity
چکیده انگلیسی مقاله Objective(s): The increasing use of methamphetamine (METH) in the last decades has made it the second most abused drug. Advancs in the area of intravenous lipid emulsion (ILE) have led to its potential application in the treatment of poisoning. The present study aims to investigate the potential role of ILE as an antidote for acute METH poisoning. Materials and Methods: Two groups of six male rats were treated by METH (45 mg/kg), intraperitoneally. Five to seven min later, they received an infusion of 18.6 ml/kg ILE 20% through the tail vein or normal saline (NS). Locomotor and behavioral activity was assessed at different time after METH administration. Body temperature and survival rates were also evaluated. Brain and internal organs were then removed for histological examination and TUNEL assay. Results: ILE therapy for METH poisoning in rats could prevent rats mortalities and returned the METH-induced hyperthermia to normal rates (P< 0.05). ILE reduced freezing and stereotyped behaviors and increased rearing responses (P< 0.05). Locomotor activity also returned to control levels especially during the last hours of the experiment. ILE administration decreased the prevalence of pulmonary emphysema in the lungs (P< 0.05 and P< 0.01) and percentages of TUNEL positive cells in the brain (P< 0.05), in comparison with the control group. Conclusion: ILE could reduce the severity of METH- induced toxicity as well as mortality rate in the animals. Intravenous infusion of lipid emulsion may save the life of patients with acute METH intoxication who do not respond to standard initial therapy.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله آمنه قدیری | ameneh ghadiri
department of toxicology, faculty of pharmacy, islamic azad university, shahreza branch, shahreza, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

لیلا اعتماد | leila etemad
pharmaceutical research center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمد مشیری | mohammad moshiri
legal medicine research center, legal medicine organization, tehran, iran


سید عادل معلم | seyed adel moallem
department of pharmacodynamics and toxicology, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

امیرحسین جعفریان | amir hossein jafarian
department of pathology, ghaem hospital, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

فرزین هادی زاده | farzin hadizadeh
biotechnology research center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمود سیفی | mahmoud seifi
biotechnology research center, school of pharmacy, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

نشانی اینترنتی http://ijbms.mums.ac.ir/article_8236.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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