|
Iranian Journal of Medical Sciences، جلد ۴۹، شماره ۳، صفحات ۱۷۶-۱۸۵
|
|
|
عنوان فارسی |
|
|
چکیده فارسی مقاله |
|
|
کلیدواژههای فارسی مقاله |
|
|
عنوان انگلیسی |
Disappearance of Imported Cases of Omicron Lineage BA.2.40 in West Kalimantan, Indonesia |
|
چکیده انگلیسی مقاله |
Background: The World Health Organization has declared Omicron as the fifth variant of concern with more than 50 mutations, particularly in the spike protein. Given increased viral infectivity due to mutations, worldwide genomic surveillance and detection of severe acute respiratory syndrome 2 (SARS-CoV-2) is essential. The present study aimed to track Omicron lineage BA.2.40 in West Kalimantan, Indonesia. Methods: In May-August 2022, nasopharyngeal swab samples (n=3,642) were collected from international travelers to West Kalimantan (active surveillance), and patients hospitalized due to SARS-CoV-2 infection (baseline surveillance). The samples were tested for Omicron lineages based on ORF1ab, N, and HV69-70del genes, followed by whole-genome sequencing. The sequences were then identified using two genomic databases, aligned against the reference genome (Wuhan/Hu-1/2019), and then compared with BA.2.40 lineage detected across the world. Phylogenetic analysis between the samples and other SARS-CoV-2 isolates was performed using molecular evolutionary genetics analysis software. Results: Based on the genomic databases, 10 isolates were identified as BA.2.40. All samples tested positive for the ORF1ab and N genes, but negative for the HV69-70del gene, which is a marker to detect the Omicron variant. Phylogenetic analysis showed the isolates were closely related to an isolate from Malaysia, an area dominated by BA.2.40. Conclusion: Omicron lineage BA.2.40 has no HV69-70 deletion in the spike protein, a marker used to screen for the Omicron variant. BA.2.40 showed a high similarity to an isolate from Malaysia and was detected only during certain periods, indicating the effect of internationally imported cases. |
|
کلیدواژههای انگلیسی مقاله |
SARS-CoV-2,
Indonesia,
Mutation,
COVID-19,
Spike glycoprotein, coronavirus |
|
نویسندگان مقاله |
Delima Fajar Liana | Department of Microbiology, School of Medicine, Universitas Tanjungpura, Pontianak, Indonesia
Virhan Novianry | Department of Biochemistry and Biomolecular, School of Medicine, Universitas Tanjungpura, Pontianak, Indonesia
Andriani Andriani | Department of Biochemistry and Biomolecular, School of Medicine, Universitas Tanjungpura, Pontianak, Indonesia
Mahyarudin Mahyarudin | Department of Microbiology, School of Medicine, Universitas Tanjungpura, Pontianak, Indonesia
Puji Astuti | Department of Biochemistry and Biomolecular, School of Medicine, Universitas Tanjungpura, Pontianak, Indonesia
|
|
نشانی اینترنتی |
https://ijms.sums.ac.ir/article_49634_2bef6cb72ef348ce0f10fef59b00e43a.pdf |
فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
کد مقاله (doi) |
|
زبان مقاله منتشر شده |
en |
موضوعات مقاله منتشر شده |
|
نوع مقاله منتشر شده |
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|